Sara Dubowsky

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The leading explanation of temperature-dependent sex determination (TSD) in reptiles postulates that (1) ovarian differentiation is directed by estrogen and that (2) estrogen is synthesized in the developing gonad following induction of aromatase expression. However, the source of steroid substrate for aromatization has not yet been identified. In addition,(More)
Follicular and luteal morphology and steroidogenic function were investigated by immunohistochemistry for cytochrome P450 17 alpha-hydroxylase (P450c17) and 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) during the estrous cycle in pigs, sheep, and cows. The theca interna of all species expressed P450c17 during follicular development. In the pig, this(More)
Ovariectomized and immature frogs were injected with estradiol, testosterone, dihydrotestosterone (DHT), or a combination of estradiol with one of the androgens. Controls were treated with oil. Dry oviduct weights were compared across groups. Ovariectomized animals treated with testosterone or estradiol plus testosterone had the largest oviducts, whereas(More)
Air pollution is a ubiquitous environmental exposure that threatens the health of people worldwide, in no small part due to the development and exacerbation of cardiovascular diseases. Daily fluctuations in pollution have been associated with acute changes in subclinical measures of disease (eg, systemic inflammation, endothelial dysfunction, and(More)
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