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Hypertension Produced by Placental Ischemia in Pregnant Rats Is Associated With Increased Soluble Endoglin Expression
The hypothesis that placental ischemia because of RUPP increases the expression of sEng and shifts the balance of angiogenic factors in the maternal circulation toward an angiostatic state is supported. Expand
Oxidative stress contributes to soluble fms-like tyrosine kinase-1 induced vascular dysfunction in pregnant rats.
Elevated maternal sFlt-1 and decreased VEGF concentrations results in increased oxidative stress that contributes to vascular dysfunction during pregnancy. Expand
Aldehyde dehydrogenase-2 (ALDH2) ameliorates chronic alcohol ingestion-induced myocardial insulin resistance and endoplasmic reticulum stress.
- Shi-Yan Li, Sara A B Gilbert, Qun Li, Jun Ren
- Biology, Medicine
- Journal of molecular and cellular cardiology
- 1 August 2009
It is revealed that aldehyde dehydrogenase-2 overexpression antagonizes chronic alcohol intake-induced cardiac insulin insensitivity and contractile defect, possibly via improvement of insulin signaling at the levels of insulin receptor, IRS, Akt, Foxo3a and JNK. Expand
The opposing roles of anti-angiogenic factors in cancer and preeclampsia.
In conclusion, elucidating mechanisms linking placental ischemia, endothelial function and subsequent cancer risk is an important step towards identifying novel therapies for cancer. Expand
Cardiac Tumors: Clinical Perspective and Therapeutic Considerations.
- Dylan Y Ren, Nathan D. Fuller, Sara A B Gilbert, Yingmei Zhang
- Current drug targets
- 30 November 2017
This mini-review tries to summarize recent understanding of the pathogenesis and therapeutics of cardiac tumors. Expand