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The gene encoding a cephalosporin-C deacetylase (CAH) from Bacillus subtilis SHS 0133 was cloned and sequenced. The nucleotide sequence contained an open reading frame encoding a polypeptide consisting of 318 amino acids, the molecular weight of which was in good agreement with the value obtained by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.(More)
We investigated the inhibitory effect of three glycyrrhizin derivatives, such as Glycyrrhizin (compound 1), dipotassium glycyrrhizate (compound 2) and glycyrrhetinic acid (compound 3), on the activity of mammalian pols. Among these derivatives, compound 3 was the strongest inhibitor of mammalian pols α, β, κ, and λ, which belong to the B, A, Y, and X(More)
The mechanism of action of dantrolene sodium, a peripherally acting muscle relaxant, is reviewed. It does not alter action potentials or responses of the contractile proteins to Ca. The amount of Ca acting on the contractile proteins during twitch must, therefore, be reduced, but since Ca uptake by the SR is not altered, Ca release from the SR must be(More)
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