Saori Kirishi

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Luminal hydrogen sulfide (H(2)S) causes colonic pain and referred hyperalgesia in mice through activation of T-type Ca(2+) channels. To test a hypothesis that H(2)S might chelate and remove endogenous Zn(2+) that inhibits the Ca(v)3.2 isoform of T-type Ca(2+) channels, facilitating visceral nociception, we asked if intracolonic (i.col.) administration of(More)
Although the budesonide and formoterol in a single inhaler for maintenance and reliever therapy has been evaluated in recent studies, the effects on eosinophilic airway inflammation remain uncertain. The purpose of this study was to compare the efficacy, including anti-inflammatory effects, of as-needed budesonide/formoterol with salbutamol in Japanese(More)
Hydrogen sulfide (H(2)S) is generated from L-cysteine by certain enzymes including cystathionine-γ-lyase (CSE) and cystathionine-β-synthase (CBS), and causes excitation of nociceptors mainly via activation of Ca(v)3.2 T-type Ca(2+) channels in the peripheral tissue, facilitating somatic and colonic pain. Here, we investigated whether sensory nerves and(More)
Cough variant asthma (CVA) is a common cause of chronic persistent cough, in which allergic airway inflammation may play a role. Although current guidelines recommend bronchodilators and anti-inflammatory drugs for the treatment, comparison of the efficacy of these medications has not been investigated. This study was designed to evaluate the effectiveness(More)
OBJECTIVE Cough variant asthma (CVA) is an important cause of chronic cough, and pathophysiological features of the disease appear to be similar to typical asthma. Because CVA is recognized as a precursor of asthma, early intervention with long-term anti-inflammatory agents may be recommended. However, the role of combination therapy with inhaled(More)
An 18-year-old man was found to have a mediastinal tumor on a chest X-ray film. Chest CT demonstrated a large tumor in the anterior mediastinum. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) of the mediastinal tumor was performed. The microscopic appearance of EBUS-TBNA and bone marrow revealed identical findings.(More)
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