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  • Bruce G. Szczepankiewicz, Christi Kosogof, +23 authors James M. Trevillyan
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2006 (First Publication: 1 June 2006)
  • The c-Jun N-terminal kinases (JNK-1, -2, and -3) are members of the mitogen activated protein (MAP) kinase family of enzymes. They are activated in response to certain cytokines, as well as byContinue Reading
  • Mei Liu, Sanyi Wang, +8 authors Gang Liu
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2007 (First Publication: 1 February 2007)
  • A new series of 4-anilinopyrimidines has been synthesized and evaluated as JNK1 inhibitors. SAR studies led to the discovery of potent JNK1 inhibitors with good enzymatic activity as well as cellularContinue Reading
  • Gang Liu, Hongyu Zhao, +10 authors Hing Leung Sham
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2006 (First Publication: 1 November 2006)
  • The structure-activity relationships of 5,6-positions of aminopyridine carboxamide-based c-Jun N-terminal Kinase (JNK) inhibitors were explored to expand interaction with the kinase specificity andContinue Reading
  • Richard A F Clark, Sanyi Wang, +18 authors Bruce A. Beutel
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2004 (First Publication: 1 June 2004)
  • Structure-activity relationships for a recently discovered novel ribosome inhibitor (NRI) class of antibacterials were investigated. Preliminary efforts to optimize protein synthesis inhibitoryContinue Reading