Santino Marchese

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Knowing the likelihood of failure of noninvasive positive pressure ventilation (NPPV) in patients with exacerbation of chronic obstructive pulmonary disease (COPD) could indicate the best choice between NPPV and endotracheal intubation instituted earlier. For this purpose, two risk charts were designed (at admission and after 2 h of NPPV) that included all(More)
OBJECTIVE To determine whether the amyotrophic lateral sclerosis functional rating scale (ALSFRS), which is a validated instrument that assesses the functional status and the disease progression in patients with amyotrophic lateral sclerosis (ALS), predicts hospital length of stay and survival time in ALS patients treated with tracheostomy-intermittent(More)
OBJECTIVES To describe survival, predictors of long-term outcome and attitudes in patients treated at home by tracheostomy-intermittent positive-pressure ventilation (TIPPV) for respiratory failure during a 10-year period (1995-2004). METHODS Seventy-seven consecutive patients were treated by TIPPV at home. Patients were divided into three groups:(More)
STUDY OBJECTIVES Evaluation of the effectiveness of negative-pressure ventilation (NPV) with the use of the iron lung vs noninvasive positive-pressure ventilation (NIPPV) in the treatment of COPD patients with acute on chronic respiratory failure. DESIGN A retrospective case-control study. SETTING Four Italian respiratory intermediate ICUs. PATIENTS(More)
OBJECTIVE To identify factors associated with tolerance and survival after noninvasive positive-pressure ventilation (NIPPV) and to investigate the influence of NIPPV on lung function in patients with ALS. METHODS NIPPV was offered to 71 patients with ALS in accordance with currently published guidelines. Effects of NIPPV on lung function and factors(More)
BACKGROUND Tracheostomy is increasingly performed in intensive care units (ICU), with many patients transferred to respiratory ICU (RICU). Indications/timing for closing tracheostomy are discussed. AIM AND METHOD We report results of a one-year survey evaluating: 1) clinical characteristics, types of tracheostomy, complications in patients admitted to(More)
Early prediction of respiratory muscle involvement and chronic hypoventilation (CH) in amyotrophic lateral sclerosis (ALS) patients can help to plan mechanical ventilatory aids and palliative care interventions well before respiratory failure occurs. To describe the natural history of the progressive pulmonary dysfunction leading to CH, and to identify(More)
Several comparative studies have been carried out in order to evaluate the possible diagnostic superiority of Computed Tomography (C.T.) vs. Magnetic Resonance Imaging (M.R.I.) in different diseases of the Central Nervous System. The present investigation is aimed at critically revising this problem also including the study of patients clinical data as a(More)
BACKGROUND Tracheostomy mechanical ventilation (TMV) is performed in amyotrophic lateral sclerosis (ALS) patients with a respiratory failure or when the non-invasive ventilation (NIV) is no longer effective. We evaluated the clinical characteristics and survival of a cohort of tracheostomized ALS patients, followed in a single ALS Clinical Center. METHODS(More)
We report the successful outcome of first-line intervention of noninvasive positive pressure ventilation (NPPV) in four patients, three of whom had hypercapnic acute respiratory failure (ARF) and one hypoxaemic ARF, secondary to pulmonary oedema. The clinical condition showed rapid improvement and the NPPV, performed together with aggressive medical(More)