Santiago Archila

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Neuronal networks produce reliable functional output throughout the lifespan of an animal despite ceaseless molecular turnover and a constantly changing environment. Central pattern generators, such as those of the crustacean stomatogastric ganglion (STG), are able to robustly maintain their functionality over a wide range of burst periods. Previous(More)
Homeostatic signaling stabilizes synaptic transmission at the neuromuscular junction (NMJ) of Drosophila, mice, and human. It is believed that homeostatic signaling at the NMJ is bi-directional and considerable progress has been made identifying mechanisms underlying the homeostatic potentiation of neurotransmitter release. However, very little is(More)
New tools for analysis of oscillatory networks using phase response theory (PRT) under the assumption of pulsatile coupling have been developed steadily since the 1980s, but none have yet allowed for analysis of mixed systems containing nonoscillatory elements. This caveat has excluded the application of PRT to most real systems, which are often mixed. We(More)
Homeostatic synaptic plasticity is a method employed by some neuronal networks to regulate their activity levels to stay within normal bounds. In this work, we investigate one particular synapse in the central-pattern-generating pyloric network of the crab Cancer borealis stomatogastric ganglion, and examine whether this synapse exhibits homeostatic(More)
Physiol. Soc.. ESSN: 1548-9221. Visit our website at American Physiological Society, 9650 Rockville Pike, Bethesda MD 20814-3991. ©2010 Int. Union Physiol. Sci./Am. the physiological developments. It is published bimonthly in February, April, June, August, October, and December by (formerly published as News in Physiological(More)
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