Learn More
Starting from the experimental data on ATP evoked calcium responses in astrocytes, a biophysical model describing these phenomena was built. The simulations showed, in agreement with the experimental findings, that the intracellular calcium fluxes mediated by the P2X and P2Y purinoreceptors are responsible for the biphasic ATP evoked calcium response in(More)
Experimental results revealed that in neocortex inhibitory fast-spiking (FS) interneurons interact also by electrical synapses (gap-junctions). They receive sensory information from thalamus and transfer it to principal cells by feedforward inhibition. Moreover, their synchronous discharge enhances their inhibitory control of pyramidal neurons. By using a(More)
Spike trains recorded under weak sinusoidal driving from central neurons of Lymnaea stagnalis appear quite irregular and envisage the possibility of an underlying chaotic process. Therefore, the sequences of interspike intervals are analyzed in the framework of non-linear dynamics. Since, for several reasons, these sequences are rather short, the analysis(More)
The synchronization properties of a pair of coupled fast spiking interneurons are studied by using the theory of weakly coupled oscillators. Four different biophysical models of the single fast spiking interneuron are used and the corresponding results are compared. It is shown that for a pair of identical coupled cells, the synchronization properties are(More)
By using a single compartment biophysical model of a fast spiking interneuron the synchronization properties of a pair of cells, coupled by electrical and inhibitory synapses, are investigated. The inhibitory and excitatory synaptic couplings are modeled in order to reproduce the experimental time course of the corresponding currents. It is shown that(More)
The 1:1 phase locking of the neural discharge to sinusoidally modulated stimuli was investigated both theoretically and experimentally. On the theoretical side, a neural encoder model, the self-inhibited leaky integrator, was considered, and the phase of the locked impulse was computed for each frequency in the locking range by imposing the condition that(More)
Environmental enrichment (EE) is an experimental protocol based on a complex sensorimotor stimulation that dramatically affects brain development. While it is widely believed that the effects of EE result from the unique combination of different sensory and motor stimuli, it is not known whether and how cortico-cortical interactions are shaped by EE. Since(More)
For a linearized version of the FitzHugh–Nagumo model, firing and resetting conditions are defined by analogy with the Integrate and Fire model. The dynamical behavior of the model, subject to periodic synaptic inputs, is investigated both theoretically and numerically, with particular emphasis on the synchronization properties. The study is then extended(More)
We analyze RR heartbeat sequences with a dynamic model that satisfactorily reproduces both the long- and the short-time statistical properties of heart beating. These properties are expressed quantitatively by means of two significant parameters, the scaling delta concerning the asymptotic effects of long-range correlation, and the quantity 1-pi(More)