Sanq Hee Kim

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The spatial organization of genomes within the mammalian cell nucleus is non-random. The functional relevance of spatial genome organization might be in influencing gene expression programs as cells undergo changes during development and differentiation. To gain insight into the plasticity of genomes in space and time and to correlate the activity of(More)
The human hypoxanthine phosphoribosyltransferase (HPRT) gene has been isolated and characterized as a set of overlapping genomic clones spanning more than 30kb of the human X chromosome. Restriction endonuclease mapping and DNA sequence analysis of exon-intron boundaries show that the HPRT gene is split into nine exons whose boundary sequences are(More)
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