Sanne J de Haart

Learn More
PURPOSE Cellular immunotherapy frequently fails to induce sustained remissions in patients with multiple myeloma, indicating the ability of multiple myeloma cells to evade cellular immunity. Toward a better understanding and effective therapeutic modulation of multiple myeloma immune evasion mechanisms, we here investigated the role of the tumor(More)
Multiple Myeloma (MM) is characterized by growth and proliferation of clonal plasma cells in the bone marrow (BM), and these plasma cells depend heavily on this BM microenvironment. In a subset of patients, the myeloma cells can spread hematogenously to soft tissues and these extramedullary myeloma (EM) lesions may be found in up to 30% of MM patients, the(More)
Targeted immunotherapy with the human anti-CD38 antibody daratumumab has recently emerged as a promising strategy for the treatment of multidrug resistant patients with multiple myeloma (MM). In experimental in vitro and in vivo settings, and in recently completed clinical trials, daratumumab achieves highly promising response rates. Despite these(More)
  • 1