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Immune disturbances are a profound feature of chronic lymphocytic leukemia (CLL). From an early stage, immune defects contribute to infectious complications and autoimmune cytopenias. Moreover,… Continue Reading
The efficacy of autologous (αβ) T-cell-based treatment strategies in chronic lymphocytic leukemia (CLL) has been modest. The Vγ9Vδ2-T cell subset consists of cytotoxic T lymphocytes with potent… Continue Reading
Chronic lymphocytic leukemia (CLL) is characterized by an acquired immune dysfunction, which may underlie the hampered efficacy of cellular immunotherapy. Most data on dampened immune responses in… Continue Reading
In chronic lymphocytic leukemia (CLL), acquired T cell dysfunction impedes development of effective immunotherapeutic strategies, through yet unresolved mechanisms. We have previously shown that CD8+… Continue Reading
Quiescent T cells primarily use oxidative phosphorylation (OXPHOS) to generate ATP, while in response to activation T cells switch to high rates of aerobic glycolysis, also known as the Warburg… Continue Reading