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These notes are a record of my graduate course entitled " Mass Problems " given in Spring 2009 at the Pennsylvania State University. The students in the course are Sankha Basu, Jacob Hendricks, Phil Hudelson, and Noopur Pathak. I am lecturing, the students are taking notes, and I am polishing the notes.
Stable isotope dilution mass spectrometry (MS) represents the gold standard for quantification of endogenously formed cellular metabolites. Although coenzyme A (CoA) and acyl-CoA thioester derivatives are central players in numerous metabolic pathways, the lack of a commercially available isotopically labeled CoA limits the development of rigorous MS-based… (More)
Rotenone, an organic pesticide and potent mitochondrial complex I inhibitor, causes Parkinson-like neurodegeneration in rodents and is implicated in human Parkinson's disease. In this rapid report, rotenone induced a dose-dependent decrease in succinyl-coenzyme A (CoA) and increase in β-hydroxybutyryl-CoA in multiple human cell lines (IC(50) < 100 nM).… (More)
Intuitionism is a constructive approach to mathematics introduced in the early part of the twetieth century by L. E. J. Brouwer and formalized by his student A. Heyting. A. N. Kolmogorov, in 1932, gave a natural but non-rigorous interpretation of intuitionism as a calculus of problems. In this document, we present a rigorous implementation of Kolmogorov's… (More)
A 63-year-old man with metastatic lung cancer admitted for severe hip pain and malaise was noted to have erratic daily morning plasma glucose concentrations, with several critical values below 40 mg/dL (Ͻ2.2 mmol/L). Each time he had a critically low laboratory glucose value, a point-of-care finger-stick glucose was found to be within reference intervals.… (More)