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PICALM is a highly validated genetic risk factor for Alzheimer's disease (AD). We found that reduced expression of PICALM in AD and murine brain endothelium correlated with amyloid-β (Aβ) pathology and cognitive impairment. Moreover, Picalm deficiency diminished Aβ clearance across the murine blood-brain barrier (BBB) and accelerated Aβ pathology in a(More)
The glucose transporter GLUT1 at the blood-brain barrier (BBB) mediates glucose transport into the brain. Alzheimer's disease is characterized by early reductions in glucose transport associated with diminished GLUT1 expression at the BBB. Whether GLUT1 reduction influences disease pathogenesis remains, however, elusive. Here we show that GLUT1 deficiency(More)
DNA damage slows DNA synthesis at replication forks; however, the mechanisms remain unclear. Cdc7 kinase is required for replication origin activation, is a target of the intra-S checkpoint, and is implicated in the response to replication fork stress. Remarkably, we found that replication forks proceed more rapidly in cells lacking Cdc7 function than in(More)
The paper discusses an approach involving digital image processing and geometric logic for recognition of two dimensional shapes of objects such as squares, circles, rectangles and triangles as well as the color of the object. This approach can be extended to applications like robotic vision and computer intelligence. The methods involved are three(More)
Pericytes are perivascular mural cells of brain capillaries. They are positioned centrally in the neurovascular unit between endothelial cells, astrocytes and neurons. This position allows them to regulate key neurovascular functions of the brain. The role of pericytes in the regulation of cerebral blood flow (CBF) and neurovascular coupling remains,(More)
The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. Central role for PICALM in amyloid– ² blood–brain barrier transcytosis and clearance. Abstract PICALM is highly validated genetic risk factor for Alzheimer's disease (AD). Here, we report that PICALM reductions in AD and murine brain(More)
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