Sankaran Subramanian

Learn More
Rapamycin is an allosteric inhibitor of mammalian target of rapamycin, and inhibits tumor growth and angiogenesis. Recent studies suggested a possibility that rapamycin renormalizes aberrant tumor vasculature and improves tumor oxygenation. The longitudinal effects of rapamycin on angiogenesis and tumor oxygenation were evaluated in murine squamous cell(More)
Electron Paramagnetic Resonance (EPR) is a spectroscopic technique that detects and characterizes molecules with unpaired electrons (i.e., free radicals.) Unlike the closely related nuclear magnetic resonance (NMR) spectroscopy, EPR is still under development as an imaging modality. Athough a number of physical factors have hindered its development, EPR's(More)
EPR spectroscopy can give biologically important information, such as tissue redox status, pO2, pH, and microviscosity, based on variation of EPR spectral characteristics (i.e., intensity, linewidth, hyperfine splitting, and spectral shape of free radical probes. EPR imaging (EPRI) can obtain 1D-3D spatial distribution of such spectral components using(More)
BACKGROUND TH-302 is a hypoxia-activated prodrug (HAP) of bromo isophosphoramide mustard that is selectively activated within hypoxic regions in solid tumors. Our recent study showed that intravenously administered bolus pyruvate can transiently induce hypoxia in tumors. We investigated the mechanism underlying the induction of transient hypoxia and the(More)
Three-dimensional Oximetric Electron Paramagnetic Resonance Imaging using the Single Point Imaging modality generates unpaired spin density and oxygen images that can readily distinguish between normal and tumor tissues in small animals. It is also possible with fast imaging to track the changes in tissue oxygenation in response to the oxygen content in the(More)
Based on the nutrient requirement of guppy, Poecilia reticulata fingerlings as reported earlier, nine experimental diets with 300 g protein, 100 g lipid and 16.72 MJ digestible energy/kg diet were formulated using snail meat (D-1), freshwater fish processing waste (D-2), surimi by-product (D-3), chicken offal (D-4), earthworm (D-5), squid (D-6), mussel(More)
Studies were carried out to assess the utility of the cellular and extracellular constituents of Bacillus megaterium for the flotation of sphalerite and galena minerals. Based on the flotation results on the individual minerals, it was observed that sphalerite was preferentially floated compared to galena. A maximum selectivity index (SI) value of 11.7 was(More)
Environmental concerns regarding the use of certain chemicals in the froth flotation of minerals have led investigators to explore biological entities as potential substitutes for the reagents in vogue. Despite the fact that several microorganisms have been used for the separation of a variety of mineral systems, a detailed characterization of the(More)
A Windows based application system for data collection, Fourier reconstruction and analysis of pure phase encoded constant-time radio frequency electron paramagnetic resonance (EPR) images, is described. The graphical user interface (GUI) of the system was written in MATLAB version 5.0, using its built-in GUI utilities. Design considerations of the(More)
  • 1