Sankar Sundaram

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To study the chemical constituents, crude ethanol extract of Embelia basaal was subjected to column chromatography and yielded two constituents. Embelin 1, a benzoquinone, and gallic acid 2, a polyphenol were isolated and are reported to be present in this species for the first time. Their structure were elucidated by spectroscopic methods like IR, NMR(More)
Benzo[a]pyrene is a procarcinogen present in environment and cigarette smoke, which could be bio-transformed in vivo to B[a]PDE, a potent carcinogen known to form DNA adducts and induce mutations. We observed that curcumin, a known chemopreventive, could significantly inhibit the survival of lung cancer cells exposed to B[a]PDE. It also downregulates(More)
We report, for the first time, the remarkable efficacy of uttroside B, a potent saponin from Solanum nigrum Linn, against liver cancer. The compound has been isolated and characterized from the leaves of Solanum nigrum Linn, a plant widely used in traditional medicine and is a rich resource of several anticancer molecules. Uttroside B, that comprises of(More)
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