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Phosphatidylinositol 5-phosphate 4-kinase regulates early endosomal dynamics during clathrin-mediated endocytosis
TLDR
PIP4K is defined as a novel regulator of early endosomal homeostasis during CME, which regulates early endOSomal dynamics and trafficking of plasma membrane receptors through clathrin-mediated endocytosis in Drosophila cells. Expand
Phosphatidylinositol 5 Phosphate 4-Kinase Regulates Plasma-Membrane PIP3 Turnover and Insulin Signaling
TLDR
PIP4Ks are key regulators of receptor tyrosine kinase signaling with implications for growth factor-dependent processes including tumor growth, T cell activation, and metabolism. Expand
A novel mass assay to measure phosphatidylinositol-5-phosphate from cells and tissues
TLDR
A simple and reliable, non-radioactive mass assay to measure total PI5P levels from cells and tissues of Drosophila, a genetically tractable multicellular model, and captures and quantifies the unique acyl chain composition ofPI5P from Drosophile tissues. Expand
A Genetic Screen in Drosophila To Identify Novel Regulation of Cell Growth by Phosphoinositide Signaling
TLDR
Three genes: Pi3K68D, Vps34 and fwd that are important for growth regulation are reported and it is suggested that these are likely to act via cell-cell interactions in the developing eye. Expand
Phosphatidylinositol 5 phosphate 4-kinase regulates plasma-membrane PIP3 turnover and insulin sensitivity in Drosophila
TLDR
It is reported that in Drosophila, phosphatidylinositol 5 phosphate 4-kinase (PIP 4 K) function at the plasma membrane is required for normal PIP 3 levels during insulin receptor activation and key regulators of receptor tyrosine kinase signalling with implications for growth factor dependent processes including tumour growth, T-cell activation and metabolism. Expand
A novel mass assay to measure phosphatidylinositol-5-phosphate from cells and tissues
TLDR
The potential of the method to quantify PI5P levels with high sensitivity from cells and tissues of multicellular organisms thus accelerating understanding ofPI5P functions in vivo is demonstrated. Expand
Phosphatidylinositol 5 phosphate 4-kinase regulates insulin sensitivity and PIP3 turnover in Drosophila.
TLDR
PIP4Ks are defined as regulators of receptor tyrosine kinase signalling with implications for growth factor dependent processes including tumour growth, T-cell activation and metabolism, which is required for normal metabolism and development. Expand
Insulin sensitivity and PIP3 turnover in Drosophila are regulated by phosphatidylinositol 5 phosphate 4-kinase
TLDR
PIP4Ks are defined as regulators of receptor tyrosine kinase signalling with implications for growth factor dependent processes including tumour growth, T-cell activation and metabolism, and PIP3 levels are controlled. Expand
Drosophila PIP4K activity regulates Insulin/PI3K signalling in cellular growth
TLDR
To what extent developmental processes are reactivated during regeneration, in the context of ROS; and whether manipulating specific ROS levels might provide a mechanism by which to induce and sustain a better, more complete regenerative response in humans, following injury is investigated. Expand