We have investigated shape deformation of the insula to get a viewpoint of how chronic alcohol consumption affects the perisylvian region and compared the deformity pattern between the left and right hemisphere. A landmark-based structural and surface shape analysis of the insula was performed in 20 patients with alcohol dependence and 20 controls matched… (More)
The aim of this study was to explore local brain atrophy of patients with alcohol dependence using a voxel-based analysis of magnetic resonance images and to investigate the relationship of those atrophic regions with drinking history and neuropsychological performances. Statistical parametric mapping was applied for the global and regional comparison of… (More)
The goal of this study was to measure the interindividual reproducibility of glutamate quantification in 1.5-T (1)H MRS of human brains. To determine the effective echo time (TE) for glutamate quantification, spectra from a phantom and 12 participants were obtained with TE = 30, 35, 40, and 144 ms (repetition time (TR) = 2000 ms and volume of interest = 4… (More)
Using proton magnetic resonance spectroscopy and magnetic resonance imaging, we investigated concentrations of various brain metabolites, including glutamate, and measured brain volumes and neuropsychological performances in 13 recently abstinent young alcoholic men compared with 18 controls. No differences were found in volumetric variables between groups… (More)
SIFamide receptor (SIFR) is a Drosophila G protein-coupled receptor for the neuropeptide SIFamide (SIFa). Although the sequence and spatial expression of SIFa are evolutionarily conserved among insect species, the physiological function of SIFa/SIFR signaling remains elusive. Here, we provide genetic evidence that SIFa and SIFR promote sleep in Drosophila.… (More)
We report rational design of amphiphilic polymers capable of making carbon nanotubes (CNTs) highly water dispersible and resistant to biofouling; such CNTs can be conjugated with bioactive molecules so as to be potential drug delivery vehicles.