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Inflammation and Alzheimer’s disease

• Y. W. Lee, Sang Bae Han, Sang-Yoon Nam, Ki-Wan Oh, Jin Tae Hong
• Archives of pharmacal research
• 2010

Alzheimer’s disease (AD) is the most common form of dementia. It is characterized by extracellular deposition of a specific protein, beta-amyloid peptide fibrils, and is accompanied by extensive loss… (More)

Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models

• Y. W. Lee, Dong Young Choi, +13 authors Jin Tae Hong
• Journal of Neuroinflammation
• 2011

BackgroundNeuroinflammation is important in the pathogenesis and progression of Alzheimer disease (AD). Previously, we demonstrated that lipopolysaccharide (LPS)-induced neuroinflammation caused… (More)

MD-2 as the target of nonlipid chalcone in the inhibition of endotoxin LPS-induced TLR4 activity.

• Eunmiri Roh, Heun-Sik Lee, +7 authors Youngsoo Kim
• The Journal of infectious diseases
• 2011

Myeloid differentiation 2 (MD-2) recognizes endotoxin lipopolysaccharide (LPS), which is required for Toll-like receptor 4 (TLR4) activity. MD-2 represents a more attractive therapeutic target than… (More)

CCR5 deficiency induces astrocyte activation, Aβ deposit and impaired memory function

• Yong Kyoung Lee, Dong Hoon Kwak, Ki-Wan Oh, Sang-Yoon Nam, Jin Tae Hong
• Neurobiology of Learning and Memory
• 2009

Activation of astrocytes has been known to be associated with amyloid-beta (Abeta) deposit and production of pro-inflammatory cytokines and chemokines that lead to neuronal cell death in the… (More)

Spatiotemporal expression of the selenoprotein P gene in postimplantational mouse embryos.

• Se-Ra Lee, Jeff Yon, +5 authors Sang-Yoon Nam
• The International journal of developmental…
• 2008

Selenoprotein P (Sepp) is an extracellular glycoprotein which functions principally as a selenium (Se) transporter and antioxidant. In order to assess the spatiotemporal expression of the Sepp gene… (More)

Resveratrol down-regulates interferon-γ-inducible inflammatory genes in macrophages: molecular mechanism via decreased STAT-1 activation.

• Eun Yong Chung, Byung Hak Kim, +5 authors Youngsoo Kim
• The Journal of nutritional biochemistry
• 2011

Resveratrol (trans-3,4',5-trihydroxystilbene) is one of nonflavonoid polyphenolic phytoalexins found in various plant species, a number of which are components of human diet including grapes and red… (More)

Protective effect of the ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on scopolamine-induced memory impairment and the inhibition of acetylcholinesterase activity

• Yong Kyung Lee, Dong Yeon Yuk, +6 authors Jin Tae Hong
• Journal of Natural Medicines
• 2009

Magnolol, honokiol, and obovatol are well-known bioactive constituents of the bark of Magnolia officinalis and have been used as traditional Chinese medicines for the treatment of neurosis, anxiety,… (More)

Soy isoflavones improve spatial delayed matching-to-place performance and reduce cholinergic neuron loss in elderly male rats.

• Yoon-bok Lee, Hyong Joo Lee, +8 authors Heon-soo Sohn
• The Journal of nutrition
• 2004

To investigate the protective activity of soy isoflavones on neurons, the effects of isoflavones on cholinergic enzyme activity, immunoreactivities of cholinergic enzyme, and delayed… (More)

l-Theanine, an amino acid in green tea, attenuates beta-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kappaB…

• Tae Il Kim, Yong Kyung Lee, +8 authors Jin Tae Hong
• Free radical biology & medicine
• 2009

Amyloid beta (Abeta)-induced neurotoxicity is a major pathological mechanism of Alzheimer disease (AD). In this study, we investigated the inhibitory effect of l-theanine, a component of green tea… (More)

Estrogen receptor independent neurotoxic mechanism of bisphenol A, an environmental estrogen

• You Mie Lee, M. J. Seong, +8 authors Jin Tae Hong
• Journal of veterinary science
• 2007

Bisphenol A (BPA), a ubiquitous environmental contaminant, has been shown to cause developmental toxicity and carcinogenic effects. BPA may have physiological activity through estrogen receptor (ER)… (More)

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