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- Publications
- Influence
MD-2 as the target of nonlipid chalcone in the inhibition of endotoxin LPS-induced TLR4 activity.
- E. Roh, Heun-Sik Lee, +7 authors Youngsoo Kim
- Biology, Medicine
- The Journal of infectious diseases
- 1 April 2011
Myeloid differentiation 2 (MD-2) recognizes endotoxin lipopolysaccharide (LPS), which is required for Toll-like receptor 4 (TLR4) activity. MD-2 represents a more attractive therapeutic target than… Expand
l-Theanine, an amino acid in green tea, attenuates beta-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kappaB…
- T. Kim, Y. K. Lee, +8 authors J. Hong
- Chemistry, Medicine
- Free radical biology & medicine
- 1 December 2009
Amyloid beta (Abeta)-induced neurotoxicity is a major pathological mechanism of Alzheimer disease (AD). In this study, we investigated the inhibitory effect of l-theanine, a component of green tea… Expand
Evaluation of the Preventive Effect of Isoflavone Extract on Bone Loss in Ovariectomized Rats
- Y. Lee, H. Lee, +4 authors Heon-soo Sohn
- Medicine, Chemistry
- Bioscience, biotechnology, and biochemistry
- 1 January 2004
To examine a potential role for soybean phytoestrogens in postmenopausal bone loss, twenty-four 12-week-old Sprague-Dawley rats were divided randomly into 4 groups and given controlled diets for 16… Expand
Spatiotemporal expression of the selenoprotein P gene in postimplantational mouse embryos.
- Sera Lee, J. Yon, +5 authors Sang-Yoon Nam
- Biology, Medicine
- The International journal of developmental…
- 2008
Selenoprotein P (Sepp) is an extracellular glycoprotein which functions principally as a selenium (Se) transporter and antioxidant. In order to assess the spatiotemporal expression of the Sepp gene… Expand
Soy isoflavones improve spatial delayed matching-to-place performance and reduce cholinergic neuron loss in elderly male rats.
- Y. Lee, H. Lee, +8 authors Heon-soo Sohn
- Biology, Medicine
- The Journal of nutrition
- 1 July 2004
To investigate the protective activity of soy isoflavones on neurons, the effects of isoflavones on cholinergic enzyme activity, immunoreactivities of cholinergic enzyme, and delayed… Expand
Resveratrol down-regulates interferon-γ-inducible inflammatory genes in macrophages: molecular mechanism via decreased STAT-1 activation.
- E. Chung, B. H. Kim, +5 authors Youngsoo Kim
- Biology, Medicine
- The Journal of nutritional biochemistry
- 1 October 2011
Resveratrol (trans-3,4',5-trihydroxystilbene) is one of nonflavonoid polyphenolic phytoalexins found in various plant species, a number of which are components of human diet including grapes and red… Expand
Estrogen receptor independent neurotoxic mechanism of bisphenol A, an environmental estrogen
- Y. M. Lee, M. J. Seong, +8 authors J. Hong
- Biology, Medicine
- Journal of veterinary science
- 1 March 2007
Bisphenol A (BPA), a ubiquitous environmental contaminant, has been shown to cause developmental toxicity and carcinogenic effects. BPA may have physiological activity through estrogen receptor (ER)… Expand
Inhibitory effect of ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on memory impairment and neuronal toxicity induced by beta-amyloid
- J. W. Lee, Y. K. Lee, B. Lee, Sang-Yoon Nam, J. Hong
- Biology, Medicine
- Pharmacology Biochemistry and Behavior
- 1 March 2010
The components of the herb Magnolia officinalis have exhibited antioxidant and neuroprotective activities. In this study, we investigated effects of ethanol extract of M.officinalis and its major… Expand
Effects of lead exposure on the expression of phospholipid hydroperoxidase glutathione peroxidase mRNA in the rat brain.
- J. Kang, D. Sul, J. K. Kang, Sang-Yoon Nam, H. Kim, E. Lee
- Chemistry, Medicine
- Toxicological sciences : an official journal of…
- 1 November 2004
Oxidative damage associated with lead in the brain has been proposed as a possible mechanism of lead toxicity. Of the many antioxidant enzymes, phospholipid hydroperoxidase glutathione peroxidase… Expand
Tissue expression and cellular localization of phospholipid hydroperoxide glutathione peroxidase (PHGPx) mRNA in male mice
- In-Jeoung Baek, Dong-Suk Seo, +9 authors Sang-Yoon Nam
- Biology, Medicine
- Journal of Molecular Histology
- 15 May 2007
Phospholipid hydroperoxide glutathione peroxidase (PHGPx) is an ubiquitous antioxidant enzyme, but the exact expression pattern in mammalian tissues is still unknown. The expression and cellular… Expand