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BACKGROUND Exercise training reduces the symptoms of chronic heart failure. Which exercise intensity yields maximal beneficial adaptations is controversial. Furthermore, the incidence of chronic heart failure increases with advanced age; it has been reported that 88% and 49% of patients with a first diagnosis of chronic heart failure are >65 and >80 years(More)
1 OBJECTIVE—Liver-specific inactivation of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) by a dominant negative transgene (L-SACC1 mice) impaired insulin clearance , caused insulin resistance, and increased hepatic lipogenesis. To discern whether this phenotype reflects a physiological function of CEACAM1 rather than the effect of the(More)
In humans, the strong statistical association between fitness and survival suggests a link between impaired oxygen metabolism and disease. We hypothesized that artificial selection of rats based on low and high intrinsic exercise capacity would yield models that also contrast for disease risk. After 11 generations, rats with low aerobic capacity scored high(More)
— Recent biological studies on water strider insects revealed the detailed mechanism of their staying and walking on water. While macro scale bodies use buoyancy to stay on water, these very light and small insects balance their weight using repulsive surface tension forces where the insect legs are covered with hydrophobic micro-hairs. Utilizing the unique(More)
BACKGROUND E. coli B (BL21), unlike E.coli K-12 (JM109) is insensitive to glucose concentration and, therefore, grows faster and produces less acetate than E. coli K-12, especially when growing to high cell densities at high glucose concentration. By performing genomic analysis, it was demonstrated that the cause of this difference in sensitivity to the(More)
Guided wave structural health monitoring is a challenging problem, in part because of the complexity of signals received in a real structure containing geometrical features and boundaries. Signals scattered from damage can be one or two orders of magnitude smaller in amplitude than the direct arrival. Detection of these small, scattered signals is often(More)
The effect of stress on Lamb wave propagation is relevant to both nondestructive evaluation and structural health monitoring because of changes in received signals due to both the associated strain and the acoustoelastic effect. A homogeneous plate that is initially isotropic becomes anisotropic under uniaxial stress, and dispersion of propagating waves(More)
Guided wave imaging has shown great potential for structural health monitoring applications by providing a way to visualize and characterize structural damage. For successful implementation of delay-and-sum and other elliptical imaging algorithms employing guided ultrasonic waves, some degree of mode purity is required because echoes from undesired modes(More)