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Gallic acid inhibits histamine release and pro-inflammatory cytokine production in mast cells.
Evidence is provided that gallic acid inhibits mast cell-derived inflammatory allergic reactions by blocking histamine release and pro-inflammatory cytokine expression, and the mechanisms of action are suggested to suggest a possible therapeutic application of this agent in inflammatory allergic diseases. Expand
Gram‐positive bacteria produce membrane vesicles: Proteomics‐based characterization of Staphylococcus aureus‐derived membrane vesicles
It is found for the first time that Gram‐positive bacteria naturally produce MVs into the extracellular milieu and these observations suggest that the secretion of MVs is an evolutionally conserved, universal process that occurs from simple organisms to complex multicellular organisms. Expand
Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells
The pharmacological actions of these flavonoids suggest their potential activity for treatment of allergic inflammatory diseases through the down-regulation of mast cell activation. Expand
Secondary Acylation of Klebsiella pneumoniae Lipopolysaccharide Contributes to Sensitivity to Antibacterial Peptides*
The view that lipopolysaccharide acylation plays a important role in providing Gram-negative bacteria some resistance to structural and innate defenses and especially the antibacterial properties of detergents and cationic defensins is supported. Expand
Signaling pathways of bisphenol A–induced apoptosis in hippocampal neuronal cells: Role of calcium‐induced reactive oxygen species, mitogen‐activated protein kinases, and nuclear factor–κB
The results suggest that calcium, ROS, ERK, and JNK are involved in BPA‐induced apoptotic cell death in HT‐22 cells. Expand
Inhibition of glial inflammatory activation and neurotoxicity by tricyclic antidepressants
The results imply that clomipramine and imipramines have antiinflammatory and neuroprotective effects in the central nervous system by modulating glial activation. Expand
A Dual Role of Lipocalin 2 in the Apoptosis and Deramification of Activated Microglia1
  • Shinrye Lee, Jayoung Lee, +6 authors K. Suk
  • Biology, Medicine
  • The Journal of Immunology
  • 1 September 2007
The results suggest that activated microglia may secrete LCN2 protein, which act in an autocrine manner to sensitize microglial cells to the self-regulatory apoptosis and to endow microglian cells with an amoeboid form, a canonical morphology of activatedmicroglia in vivo. Expand
Aluminum-maltolate induces apoptosis and necrosis in neuro-2a cells: potential role for p53 signaling.
Results show for the first time that p53 is induced by Al in neuron-like cells and suggest that the p53-dependent intrinsic pathway may be responsible for Al-induced apoptosis. Expand
The comparative effects of mesoporous silica nanoparticles and colloidal silica on inflammation and apoptosis.
The MPS nanoparticles exhibit better biocompatibility than colloidal silica and promise excellent potential usage in the field of biomedical and biotechnological applications and should be carefully designed. Expand
RKIKK motif in the intracellular domain is critical for spatial and dynamic organization of ICAM-1: functional implication for the leukocyte adhesion and transmigration.
Findings demonstrate that (507)RKIKK(511) is an essential motif for the microvillus ICAM-1 presentation and further suggest a novel regulatory role for IC AM-1 topography in leukocyte TEM. Expand