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  • Sang Hoon Lee, Daniel E Lopes de Menezes, +8 authors Carla Heise
  • Medicine, Biology
  • Clinical Cancer Research
  • 2005 (First Publication: 15 May 2005)
  • Purpose: To evaluate the therapeutic and biological effects of CHIR-258, an orally bioavailable, potent inhibitor of class III-V receptor tyrosine kinases, in colon cancer models. ExperimentalContinue Reading
  • Daniel E Lopes de Menezes, Jing Peng, +10 authors Carla Heise
  • Biology, Medicine
  • Clinical Cancer Research
  • 2005 (First Publication: 15 July 2005)
  • Purpose: Fms-like tyrosine kinase 3 (FLT3) encodes a receptor tyrosine kinase (RTK) for which activating mutations have been identified in a proportion of acute myelogenous leukemia (AML) patientsContinue Reading