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  • Sang Hong Lee, Jian Yang, Michael Goddard, Peter M. Visscher, Naomi R. Wray
  • Computer Science, Medicine, Biology
  • Bioinform.
  • 2012 (First Publication: 1 October 2012)
  • SUMMARY Genetic correlations are the genome-wide aggregate effects of causal variants affecting multiple traits. Traditionally, genetic correlations between complex traits are estimated from pedigreeContinue Reading
  • Naomi R. Wray, Sang Hong Lee, Divya Mehta, Anna A. E. Vinkhuyzen, Frank Dudbridge, Christel M Middeldorp
  • Psychology, Biology, Medicine
  • Journal of child psychology and psychiatry, and…
  • 2014 (First Publication: 1 October 2014)
  • BACKGROUND Despite evidence from twin and family studies for an important contribution of genetic factors to both childhood and adult onset psychiatric disorders, identifying robustly associatedContinue Reading
  • Sonja I. Berndt, Stefan Gustafsson, +319 authors Erik Ingelsson
  • Biology, Medicine
  • Nature Genetics
  • 2013 (First Publication: 7 April 2013)
  • Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In aContinue Reading