Sang-Cheol Chi

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Tacrolimus (TCR; also FK-506 and trade name prograf®), an antibiotic of macrolide family and a novel immunosuppressive agent, is a natural product of actinomycete Streptomyces tskubaensis. But TCR is poorly soluble in water (0.012 mg/mL), so its bioavailability is low and irregular. The aim of this study is to characterize physicochemical properties of TCR(More)
Hypoglycemia caused by palmitic-acid modified exendin-4 (Pal-Ex4) administered via the pulmonary route was evaluated and compared with that caused by native Ex4. Pal-Ex4 and Ex4 in solution (each 50 μl) were administered using a microsprayer directly into the trachea of type 2 diabetic db/db mice at 75 or 150 nmol/kg. The lung depositions of Cy5.5-labeled(More)
Ondansetron was formulated into a transdermal matrix patch to reduce side effects and improve patient compliance. The effects of adhesive (polyisobutylene rubber, acrylic, and styrene butadiene rubber), crosslinker content (aluminum), vehicle (lactic acid), and drug amount on ondansetron skin permeation rate were investigated using excised hairless mouse(More)
The purpose of this study was to evaluate the effect of the method of excipients addition (intra-granularly or extra-granularly) and type of excipients on the stability of pramipexole dihydrochloride monohydrate (PRM) tablets. Corn starch, pre-gelatinized starch, dibasic calcium phosphate, microcrystalline cellulose or lactose anhydrous were used as(More)
The aim of this study was to make use of small size of immediate-release (IR) pellet and amorphous state of solid dispersion to increase solubility of celecoxib (CLX), a drug in BCS class II. Primary, binary and ternary solid dispersions were developed to choose the final components for solid dispersion. A ternary novel solid dispersion was prepared by(More)
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