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During 1989 stool specimens from hospitalised children with gastroenteritis at Ga-Rankuwa Hospital in South Africa were examined for the presence of rotaviruses. Overall 16% of the children were positive for rotavirus. However, 43% of the rotavirus positive patients were infected in the hospital. Further characterisation of the rotavirus strains was(More)
Different hepatitis C virus (HCV) genotypes may be associated with viral load, severity of liver disease, hepatocellular carcinoma, geographical location and sensitivity to interferon. In this study the prevalence of HCV-RNA and distribution of HCV genotypes was investigated in anti-HCV-positive patients admitted to Ga-Rankuwa Hospital during 1994 and 1995.(More)
Objective and Design: To determine the effects of anti-inflammatory and anti-rheumatic drugs on paw swelling and changes in plasma levels of acute phase proteins (APPs) during acute inflammation in the rat.¶Materials and Methods: Inflammation was induced in rats by the injection of adjuvant and the animals were bled five days later and plasma levels of(More)
BACKGROUND Human rotavirus vaccine (HRV; i.e., Rotarix) reduced the incidence of severe rotavirus gastroenteritis (RVGE) by 77% (95% Confidence interval: 56-88%) during the first year of life in South Africa. Persistence of HRV-derived protection against RVGE during subsequent rotavirus seasons, although evident in industrialized settings, remains to be(More)
BACKGROUND Rotaviruses are the most important cause of severe acute gastroenteritis worldwide in children <5 years of age. The human, G1P[8] rotavirus vaccine Rotarix™ significantly reduced severe rotavirus gastroenteritis episodes in a Phase III clinical trial conducted in infants in South Africa and Malawi. This paper examines rotavirus vaccine efficacy(More)
A novel beta-lactamase enzyme produced by a strain of Pseudomonas paucimobilis is described. The enzyme differs from other recorded beta-lactamases from Gram-negative aerobic bacteria. It was constitutive, and had the characteristics of a penicillinase. One single band of beta-lactamase activity at pI 4.6 was seen on iso-electric focusing. The enzyme had a(More)
Significance of the antibody levels to hepatitis B surface antigen (anti-HBs) as an indicator of protective immunity has recently been stressed. The aim of this study was to quantitatively evaluate the immune response in dental personnel vaccinated with Engerix B recombinant DNA vaccine (SK&F). The vaccine was administered to staff at the MEDUNSA Dental(More)
BACKGROUND Because baboons are being considered as a source of xenografts for human liver transplantation in patients with hepatitis B virus- (HBV) induced cirrhosis to forestall infection of the graft by the virus, we undertook a study to ascertain if baboons are resistant to HBV infection. METHODS Six chacma baboons were inoculated with serum containing(More)
Antibodies to human immunodeficiency virus 1 (HIV-1) and human T lymphotropic virus type 1 (HTLV-I) have been identified in various population groups living in southern and central Africa. Sera from 291 !Kung Bushmen in Bushmanland, Namibia were examined for the presence of antibodies to HIV-1 and HIV-2 and to HTLV-I. Initial screening for HIV-1/2 by two(More)