Sandy Flann

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We report 3 cases of lymphomatoid papulosis (LyP) with a CD56+, cytotoxic immunophenotype. All 3 patients presented with clinical histories typical of LyP, with one patient having associated mycosis fungoides. Histologically, two cases were type A LyP and one was type B. All 3 cases demonstrated a T-cell receptor clone in lesional skin without evidence of(More)
The role of ubiquitin in development of the mammalian brain has been studied using a monoclonal antibody, RHUb1, specific for ubiquitin. Immunodevelopment of western blots of homogenate samples of the cerebral cortex, hippocampus and cerebellum prepared from animals of known postnatal age show marked developmental changes in conjugate level. Striking(More)
Precalcaneal congenital fibrolipomatous hamartoma (PCFH) is a condition that is seldom reported in the paediatric literature and rarely in the dermatological literature. It has other disparate and confusing names and as histology is rarely obtained, the condition may be under-reported. We describe this disorder in the male twin of a pair of nonidentical(More)
  • Sandy Flann, R Moss, T Thompson, M Clement, K Powell, S Munn
  • The British journal of dermatology
  • 2008
patients with NS. The mean caspase-1 activities of SC in the patients with NS (n = 2) and in healthy controls (n = 9) were 524Æ95 (range 522Æ9–527Æ0) and 157Æ63 (range 92Æ7–237Æ5), respectively. The caspase-1 activity of SC in the patients with NS was 3Æ3-fold that in the healthy controls (Fig. 2b). Caspase-1 is synthesized as a procaspase-1, which is(More)
Necrobiotic xanthogranuloma is a rare cutaneous condition that can be mistaken for atypical necrobiosis lipoidica. It has a strong association with a paraproteinaemia, which may progress to frank haematological malignancy. We describe four patients with variable cutaneous features, and their treatment response.
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