Sandy Cowan

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Porins form aqueous channels that aid the diffusion of small hydrophilic molecules across the outer membrane of Gram-negative bacteria. The crystal structures of matrix porin and phosphoporin both reveal trimers of identical subunits, each subunit consisting of a 16-stranded anti-parallel beta-barrel containing a pore. A long loop inside the barrel(More)
The structure of the bifunctional, pyridoxal phosphate-dependent enzyme dialkylglycine decarboxylase was determined to 2.1-angstrom resolution. Model building suggests that a single cleavage site catalyzes both decarboxylation and transamination by maximizing stereoelectronic advantages and providing electrostatic and general base catalysis. The enzyme(More)
Oats are a low input cereal widely grown across the world as both a grain and forage crop. Significant areas of production are in Northern Europe and North America and also in China and Australia. Although a traditional crop in many countries, in the last 50 years there has been a significant shift in oat production as a consequence of changing agricultural(More)
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