Sandro Carlini

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Protein truncation test (PTT) and single-strand conformation polymorphism (SSCP) assay were used to scan the BRCA1 and BRCA2 genes in 136 unrelated Italian breast/ovarian cancer patients. In the sample tested, BRCA1 and BRCA2 equally contributed to site-specific breast cancer patients who reported one to two breast cancer-affected first-/ second-degree(More)
The use of reverse transcription-PCR (RT-PCR) to analyze cells in the blood of cancer patients for the detection of mRNA expressed in tumor cells has implications for both the prognosis and the monitoring of cancer patients for the efficacy of established or experimental therapies. Carci-noembryonic antigen (CEA) is expressed on ϳ95% of colorectal, gastric,(More)
Using PTT combined with SSCP, we screened the entire BRCA1 and BRCA2 coding sequences in 136 unrelated patients, recruited from oncology units in Rome and Naples and including 107 females with breast cancer, 10 with ovarian cancer and 19 males affected with breast cancer. Female patients were recruited on the basis of family history, mostly indicative of(More)
The present study was designed to investigate whether a correlation exists between IL-6, TNF-alpha and coagulation (Thrombin-antithrombin, TATc) or fibrinolysis (D-dimer) activation in non-small cell lung cancer (NSCLC) patients. One hundred thirty patients with NSCLC (n=65, 53 males, mean age 65 +/- 8, adenocarcinoma n=32, squamous cancer n=33) or chronic(More)
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