Sandrine M. Couldwell

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Dysregulation of hypoxia-inducible transcription factors HIF-1α and HIF-2α correlates with poor prognosis in human cancers; yet, divergent and sometimes opposing activities of these factors in cancer biology have been observed. Adding to this complexity is that HIF-1α apparently possesses tumor-suppressing activities, as indicated by the loss-of-function(More)
Spontaneous regression of a cerebral arteriovenous malformation (AVM) is a rare occurrence. The authors describe a patient presenting with a ruptured AVM with a feeding artery aneurysm during second trimester of pregnancy. The feeding artery with aneurysm was clipped and the hematoma removed. The AVM subsequently spontaneously regressed by serial(More)
Cidea and Cidec play an important role in regulating triglyceride storage in liver and adipose tissue. It is not known if the Cidea and Cidec genes respond to a high fat diet (HFD) or exercise training, two interventions that alter lipid storage. The purpose of the present study was to determine the effect of a HFD and voluntary wheel running (WR) on Cidea(More)
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