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Mitochondria exert crucial physiological functions that create complex links among nutrition, health, and disease. While mitochondrial dysfunction with subsequent impairment of oxidative… Expand
Molecular bases of inherited deficiencies of mitochondrial respiratory chain complex I are still unknown in a high proportion of patients. Among 45 subunits making up this large complex, more than… Expand
Complex I (or NADH-ubiquinone oxidoreductase), is by far the largest respiratory chain complex with 38 subunits nuclearly encoded and 7 subunits encoded by the mitochondrial genome. Its deficiency is… Expand
SummaryDiabetes mellitus is occasionally observed in patients with skeletal muscle respiratory chain deficiency, suggesting that skeletal muscle mitochondrial dysfunction might play a pathogenic role… Expand
Le deficit en complexe I (CI) est defaut le plus frequent de la chaine respiratoire humaine. Jusqu'a recemment, la recherche de mutations chez les patients se limitait souvent aux genes des… Expand
Summary The highly complex functioning of mitochondria, their two-fold genetic origin, their particular mode of transmission and their widespread distribution in the organism, account for the… Expand