Sandrah P. Eckel

Frank D. Gilliland7
Muhammad T. Salam6
Edward B. Rappaport3
7Frank D. Gilliland
6Muhammad T. Salam
3Edward B. Rappaport
3William S. Linn
3Kiros Berhane
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BACKGROUND The fractional concentration of nitric oxide in exhaled air (FeNO) potentially detects airway inflammation related to air pollution exposure. Existing studies have not yet provided conclusive evidence on the association of FeNO with traffic-related pollution (TRP). OBJECTIVES We evaluated the association of FeNO with residential TRP exposure in(More)
  • Sandrah P. Eckel, William S. Linn, Kiros Berhane, Edward B. Rappaport, Muhammad T. Salam, Yue Zhang +1 other
  • 2014
The fractional concentration of exhaled nitric oxide (FeNO) is a biomarker of airway inflammation that is being increasingly considered in clinical, occupational, and epidemiological applications ranging from asthma management to the detection of air pollution health effects. FeNO depends strongly on exhalation flow rate. This dependency has allowed for the(More)
The ability to make scientific findings reproducible is increasingly important in areas where substantive results are the product of complex statistical computations. Reproducibility can allow others to verify the published findings and conduct alternate analyses of the same data. A question that arises naturally is how can one conduct and distribute(More)
  • Muhammad T. Salam, Pi-Chu Lin, Sandrah P. Eckel, W. James Gauderman, Frank D. Gilliland
  • 2016
There is an error in footnote (c) of Table 1. The correct sentence is: P-values from linear regression testing overall association of the variable with natural log-transformed FeNO level. Statistically significant P-values are in bold. access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,(More)
Nitric oxide (NO) is endogenously released in the airways, and the fractional concentration of NO in exhaled breath (FeNO) is now recognized as a surrogate marker of eosinophilic airway inflammation that can be measured using a noninvasive technique suitable for young children. Although FeNO levels are affected by several factors, the most important(More)
  • Muhammad T. Salam, Pi-Chu Lin, Sandrah P. Eckel, W. James Gauderman, Frank D. Gilliland, Markus M Bachschmid
  • 2015
BACKGROUND Exhaled nitric oxide (FeNO), a biomarker of airway inflammation, predicts asthma risk in children. We previously found that the promoter haplotypes in inducible nitric oxide synthase (NOS2) and exposure to residential traffic independently influence FeNO level. Because NOS2 is inducible by environmental exposures such as traffic-related exposure,(More)
  • Yue Zhang, Kiros Berhane, Sandrah P. Eckel, Muhammad T. Salam, William S. Linn, Edward B. Rappaport +3 others
  • 2015
While the fractional concentration of exhaled nitric oxide (FeNO) has proven useful in asthma research, its exact role in clinical care remains unclear, in part due to unexplained inter-subject heterogeneity. In this study, we assessed the hypothesis that the effects of determinants of the fractional concentration of exhaled nitric oxide (FeNO) vary with(More)
Previous studies have investigated the associations between exposure to ambient air pollution and biomarkers of physiological pathways, yet little has been done on the comparison across biomarkers of different pathways to establish the temporal pattern of biological response. In the current study, we aim to compare the relative temporal patterns in(More)
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