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Vigilant Keratinocytes Trigger Pathogen-Associated Molecular Pattern Signaling in Response to Streptococcal M1 Protein
TLDR
Keratinocytes participate in a proinflammatory manner in streptococcal pattern recognition and that expression of the chemoattractant IL-8 by keratinocytes constitutes an important protective mechanism against strePTococcal M1 protein.
Heparin-Binding Protein Release Is Strongly Induced by Leptospira Species and Is a Candidate for an Early Diagnostic Marker of Human Leptospirosis
TLDR
It is found that leptospires and their secreted products induce the release of HBP from stimulated neutrophils through a controlled degranulation mechanism, and HBP is proposed as a new early screening biomarker for humanLeptospirosis.
Cold Atmospheric Plasma Disarms M1 Protein, an Important Streptococcal Virulence Factor
TLDR
Results show that CAP abolishes the ability of M1 protein to trigger inflammatory host responses, supporting the benefits of using CAP to combat infections and may open new research avenues for the development of novel approaches for the treatment of skin and wound infections caused by S. pyogenes.
Leucocyte recruitment and molecular fortification of keratinocytes triggered by streptococcal M1 protein
TLDR
It is demonstrated that M1 protein is a critical virulence factor that can augment streptococcal skin infection suggesting that the protein is an interesting target for drug development.
Vigilant Keratinocytes Trigger PAMP Signaling in Response to Streptococcal M1 Protein
The human skin exerts many functions in order to maintain its barrier integrity and protect the host from invading microorganisms. One such pathogen is Streptococcus pyogenes, which can cause a
Bacterial virulence or exorbitant host response? On innate immunity against the streptococcal M1 protein.
TLDR
New mechanisms and host responses to combat bacterial virulence important for the pathology of infectious diseases are explored, and new virulence factors of Leptospira responsible for triggering massive HBP release from neutrophils are identified.