Sandra Souza Rodrigues

Learn More
Hereditary hemochromatosis (HH) is the most common genetic disease among individuals of European descent. Two mutations (845G-->A, C282Y and 187C-->G, H63D) in the hemochromatosis gene (HFE gene) are associated with HH. About 85-90% of patients of northern European descent with HH are C282Y homozygous. The prevalence of HH in the Brazilian population, which(More)
BACKGROUND AND AIMS Iron deposits in the liver and abnormalities in serum iron biochemistry are frequently observed in patients with chronic liver diseases, but data for patients with hepatitis B virus (HBV) infection are scarce. Moreover, the role of HFE mutations in iron deposits in this condition remains unknown. The aim of the present study was to(More)
TNF microsatellite and HLA class II polymorphisms were studied in 28 recently diagnosed Brazilian patients presenting type 1 diabetes mellitus (T1DM) and in 120 healthy controls. TNFa-e and HLA-DRB1/DQB1 alleles were identified using sets of sequence-specific primers. Compared to controls, the DRB1*03 and DQB1*02 allele groups, TNFa1 allele, and the(More)
This study evaluated the association of polymorphisms in the IL-18 (-607C/A and -137C/G), IFNγ (+874 A/T), and TNF (-238 A/G and -308 A/G) genes with susceptibility to HBV infection and severity of liver injury. A total of 259 chronic HBV-infected patients followed at the University Hospital, Faculty of Medicine of Ribeirão Preto, São Paulo, Brazil, and 202(More)
The complex fac-[Mo(CO)(3)(histidinate)]Na has been reported to be an effective CO-Releasing Molecule in vivo, eliciting therapeutic effects in several animal models of disease. The CO releasing profile of this complex in different settings both in vitro and in vivo reveals that the compound can readily liberate all of its three CO equivalents under(More)
This paper presents the results concerning an update of a previous mapping study about usability heuristics applied in Heuristic Evaluation of mobile usability. Heuristic Evaluation is a popular method of usability evaluation, and its applicability to inspect the mobile usability may be improved by the development of context and audience specific(More)
BACKGROUND AND AIMS HLA-G has well-recognized immunomodulatory properties, and this molecule is frequently expressed in the livers of hepatitis B virus (HBV)-infected patients. Because the HLA-G 14 bp-insertion/deletion polymorphism (rs371194629) has been associated with the magnitude of HLA-G expression, we evaluated this polymorphism in the recognized(More)
Population ageing represents an opportunity and a challenge for Gerontechnology innovation. The usability should be considered in the design of applications on mobile devices for older users because as we age, cognitive functions begin to decline and older people may have more difficulty to cope with managing a eventfully daily routine, even those(More)
Despite potential for preventing social isolation and loneliness, providing health care access and other benefits, older persons tend to be less receptive to digital devices. Elderly people frequently appoint complex interface and perceived usefulness as cause for not using health-related ICT. There is little information about preferences and interests of(More)
  • 1