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Tissue factor (TF) is a transmembrane glycoprotein cofactor of activated blood coagulation factor VII (FVIIa) that is required for hemostatic thrombin generation at sites of blood vessel injury. Membrane-associated TF detected in circulating blood of healthy subjects, referred to as intravascular or circulating TF has been shown to contribute to(More)
The solution of fluid flows, modeled using the Navier-Stokes or Euler equations, fully coupled with structures/solids is considered. Simultaneous and partitioned solution procedures, used in the solution of the coupled equations, are briefly discussed, and advantages and disadvantages of their use are mentioned. In addition , a simplified stability analysis(More)
In pregnant women, the diabetic condition results in a three- to fivefold increased risk for fetal cardiac malformations as a result of elevated glucose concentrations and the resultant osmotic stress in the developing embryo and fetus. Heart development before septation in the chick embryo was studied under two hyperglycemic conditions. Pulsed(More)
During developmental stages, biomechanical stimuli on cardiac cells modulate genetic programs, and deviations from normal stimuli can lead to cardiac defects. Therefore, it is important to characterize normal cardiac biomechanical stimuli during early developmental stages. Using the chicken embryo model of cardiac development, we focused on characterizing(More)
Embryonic heart formation results from a dynamic interplay between genetic and environmental factors. Blood flow during early embryonic stages plays a critical role in heart development, as interactions between flow and cardiac tissues generate biomechanical forces that modulate cardiac growth and remodeling. Normal hemodynamic conditions are essential for(More)
The measurement of blood-plasma absolute velocity distributions with high spatial and temporal resolution in vivo is important for the investigation of embryonic heart at its early stage of development. We introduce a novel method to measure absolute blood flow velocity based on high speed spectral domain optical coherence tomography (OCT) and apply it to(More)
Several applications-for example, study of biological tissue movement and organ growth-require shape correspondence with a physical basis, especially for shapes or regions lacking distinctive features. For this purpose, we propose the adaptation of mechanical strain, a well-established physical measure for deformation, to the problem of constructing shape(More)
In many applications in engineering and science, it is important to know whether the response of a nonlinear system is chaotic. This characterization is possible by the evaluation of the one-dimensional Lyapunov characteristic exponent (LCE). In this paper, a numerical procedure to calculate the LCE of continuous systems discretized using finite element(More)
Pulmonary surfactant lowers surface tension in the lungs. Physiological studies indicate two key aspects of this function: that the surfactant film forms rapidly; and that when compressed by the shrinking alveolar area during exhalation, the film reduces surface tension to very low values. These observations suggest that surfactant vesicles adsorb quickly,(More)