Sandra Rees

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Cerebral cortical development involves complex changes in cellular architecture and connectivity that occur at regionally varying rates. Using diffusion tensor magnetic resonance imaging (DTI) to analyze cortical microstructure, previous studies have shown that cortical maturation is associated with a progressive decline in water diffusion anisotropy. We(More)
INTRODUCTION Cerebral white-matter (WM) abnormalities on magnetic resonance imaging (MRI) correlate with neurodevelopmental disability in infants born prematurely. RESULTS Quantitative histological measures of WM and ventricular volumes correlated with qualitative MRI scores of WM volume loss and ventriculomegaly. Diffuse astrocytosis was associated with(More)
The cerebral cortex is composed of regions with distinct laminar structure. Functional neuroimaging results are often reported with respect to these regions, usually by means of a brain "atlas". Motivated by the need for more precise atlases, and the lack of model-based approaches in prior work in the field, this paper introduces a novel approach to(More)
OBJECTIVE Caffeine improves neurological outcome in very preterm infants, but the mechanisms responsible for this neurological benefit are unknown. The objective of this study was to assess whether caffeine influenced brain macro- or microstructural development in preterm infants. METHODS Seventy preterm infants <1,251 g birthweight randomly allocated to(More)
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