Sandra Mourad Younan

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BACKGROUND The hippocampus is a key brain area for many forms of learning and memory and is particularly sensitive to changes in glucose homeostasis. AIM OF THE WORK To investigate in experimentally induced type 1 and 2 diabetes mellitus in rat model the effect of  diabetes mellitus on cognitive functions and related markers of hippocampal synaptic(More)
Ischemia–reperfusion (I/R) cannot be avoided in liver transplantation procedures, and apoptosis is a central mechanism of cell death after liver reperfusion. Protective effect of recombinant erythropoietin (rhEPO) on liver apoptosis has not been clearly investigated. This work investigated intraportal (IP) rhEPO-protective effect in a rat model of hepatic(More)
Among the several disorders induced by sepsis, acute kidney injury (AKI) represents the most important economic burden problem that is associated with high mortality and morbidity rates. The aim of this study was to investigate the anti-inflammatory effects of ghrelin in sepsis-induced AKI and the possible role of vagus nerve. Five groups were included:(More)
The association of obesity with type 2 diabetes mellitus has been recognized for years. In type 2 diabetes, there is a possibility that an important part of the impaired insulin secretion is due to the gastric inhibitory polypeptide (GIP) hormone. This study investigated changes that occur in the pancreatic GIP receptors' (GIP-Rs) expression and in GIP(More)
Obesity is an important risk factor for heart disease. This study investigated the effects of omega-3 (omega-3) on reversal of high fat (HF) diet-induced changes in the expression of the cardiac adiponectin and adiponectin receptors R1 and R2. Male rats were fed low-fat (LF; 10% energy from fat) or HF (45% energy from fat) for 16 weeks, LF-omega-3 or a(More)
Cognitive dysfunction is a common complication of diabetes mellitus however, less addressed and recognized. This study aimed to investigate the effect of type 1 and 2 diabetes on cognitive functions and related markers of hippocampal synaptic plasticity and the possible impact of blocking NMDA receptors by memantine. Seven rat groups were included in this(More)
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