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Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis
A growing body of evidence indicates that dysregulation of cerebral biometals (Fe, Cu, Zn) and their interactions with APP and Abeta amyloid may contribute to the Alzheimer's amyloid pathology, andExpand
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FDA-preapproved drugs targeted to the translational regulation and processing of the amyloid precursor protein
The 5′ untranslated region (5′UTR) of the transcript encoding the Alzheimer’s amyloid precursor protein (APP) is a key regulatory sequence that determines the amount of intracellular APP holoproteinExpand
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Drug discovery targeted to the Alzheimer’s APP mRNA 5′-untranslated region
We screened for drugs that specifically interact with the 5′-untranslated region of the mRNA encoding the Alzheimer’s amyloid precursor protein (APP). Our goal was to use newly discovered APP 5′ UTRExpand
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Alzheimer’s disease drug discovery targeted to the APP mRNA 5′Untranslated region
We performed a screen for drugs that specifically interact with the 5′ untranslated region of the mRNA coding for the Alzheimer’s Amyloid Precursor Protein (APP). Using a transfection based assay, inExpand
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Peroxidase Activity of Cyclooxygenase-2 (COX-2) Cross-links β-Amyloid (Aβ) and Generates Aβ-COX-2 Hetero-oligomers That Are Increased in Alzheimer's Disease*
Oxidative stress is associated with the neuropathology of Alzheimer's disease. We have previously shown that human Aβ has the ability to reduce Fe(III) and Cu(II) and produce hydrogen peroxideExpand
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Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease.
Oxidative stress is associated with the neuropathology of Alzheimer's disease. We have previously shown that human Abeta has the ability to reduce Fe(III) and Cu(II) and produce hydrogen peroxideExpand
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