Learn More
Patterns of vibrotactile stimulation were delivered to the index fingertips of naive blindfolded subjects. The attributions made by these subjects when they were allowed to experience transformations of vibrotactile stimulation correlated with self-movement were assessed. Although the subjects became aware of the relationship between self-movement and(More)
The present research utilized aspects of the Principles and Parameters Approach (P&PA; Chomsky, 1991, 1993) in linguistic theory as well as findings from the psycholinguistic literature as a basis for examining sentence production in aphasic individuals. We examined the production of particular wh-movement constructions--wh-questions requiring movement of(More)
Tumor-specific screening of investigational anticancer drugs is a new approach to cytotoxic drug screening. A tumor-specific drug screening model has been designed using established human neuroblastoma cell lines. In vitro drug sensitivity was studied using a modification of the human tumor stem cell assay. Eleven cell lines were tested initially for colony(More)
An adriamycin-resistant human breast tumor cell line MDA-A1 R was generated by step-wise selection in increasing concentrations of drug from the parent cell line MDA-MB-231. MDA-A1 R cells grow as loosely attached cell aggregates with a doubling time of 28–32 h; the MDA-MB-231 parent cell line grows as a standard monolayer culture with a 20-h doubling time.(More)
Acoustic metrics extracted from speech have the potential to serve as novel biomarkers for a variety of neurological and neurodevelopmental conditions, as is evidenced by the rapidly growing corpus of research articles studying the links between brain impairments and speech. In this paper, we discuss the advantages and the disadvantages of speech biomarkers(More)
Previous research suggests that the noradrenergic system modulates flexibility of access to the lexical-semantic network, with propranolol benefiting normal subjects in lexical-semantic problem solving tasks. Patients with Broca's aphasia with anomia have impaired ability to access appropriate verbal output for a given visual stimulus in a naming task.(More)
BACKGROUND: Some individuals with agrammatic aphasia have difficulty producing verbs when naming and generating sentences (Miceli, Silveri, Villa, & Caramazza, 1984; Saffran, Schwartz, & Marin, 1980; Zingeser & Berndt, 1990). And when verbs are produced there is an over-reliance on verbs requiring simple argument structure arrangements (Thompson, Lange,(More)
Perceptual learning was examined in two experiments in which subjects, originally unfamiliar with vibrotactile stimulation, were required to identify dynamic vibrotactile patterns with static visual patterns of the same two-dimensional shapes. In Experiment 1 we examined changes in performance with practice under a variety of vibrotactile spatial and(More)