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OBJECTIVE To determine prevalence of radiographic evidence of osteoarthritis in 4 diarthrodial joints of dogs with restricted feed intake, compared with dogs without restricted feed intake. DESIGN Paired feeding study. ANIMALS 48 Labrador Retrievers. PROCEDURE Dogs in litters from 7 dams and 2 sires were paired by sex and weight within litters and(More)
Intracerebroventricular (i.c.v.) administration of NG-monomethyl-L-arginine monoacetate (NMMA; 500 micrograms; 402 mM) and NG-nitro-L-arginine methyl ester (NAME; 270 micrograms; 200 mM), inhibitors of nitric oxide synthase, enhanced the rise in oxytocin but not vasopressin levels in plasma of conscious rats following 24 h of water deprivation. This effect(More)
OBJECTIVE To evaluate the effects of 25% diet restriction on life span of dogs and on markers of aging. DESIGN Paired feeding study. ANIMALS 48 Labrador Retrievers. PROCEDURES Dogs were paired, and 1 dog in each pair was fed 25% less food than its pair-mate from 8 weeks of age until death. Serum biochemical analyses were performed, body condition was(More)
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