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A Dominant-negative p38 MAPK Mutant and Novel Selective Inhibitors of p38 MAPK Reduce Insulin-stimulated Glucose Uptake in 3T3-L1 Adipocytes without Affecting GLUT4 Translocation*
Participation of p38 mitogen-activated protein kinase (p38) in insulin-induced glucose uptake was suggested using pyridinylimidazole p38 inhibitors (e.g. SB203580). However, the role of p38 inExpand
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Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression.
Serine and threonine kinases may contribute to insulin resistance and the development of type 2 diabetes. To test the potential for members of the mitogen-activated protein (MAP) kinase family toExpand
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PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice
The role of protein-tyrosine phosphatase 1B (PTP1B) in diabetes was investigated using an antisense oligonucleotide in ob/ob and db/db mice. PTP1B antisense oligonucleotide treatment normalizedExpand
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Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice.
Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin receptor (IR) signal transduction and a drug target for treatment of type 2 diabetes. Using PTP1B antisense oligonucleotidesExpand
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T cell activation induces a noncoding RNA transcript sensitive to inhibition by immunosuppressant drugs and encoded by the proto-oncogene, BIC.
In a search for novel early T cell activation transcripts, we identified expressed sequence tags (ESTs) more abundantly expressed in normal human CD4(+) T lymphocytes fully activated by a 5 hExpand
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Management of a Tracheal Tear during Laryngopharyngoesophagectomy with Gastric Pull-up
Laceration of the posterior tracheal wall is one of the risks of transhiatal esophagectomy. Various methods of repairing such lacerations have been described; many of these methods involve aExpand
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P035: Continuing Trends in Awake Tracheotomy Airway Intervention
Objectives: (1) Understand patient and disease characteristics that necessitate urgent surgical airway intervention. (2) Learn which of these factors are predictive of decannulation. Methods: Here weExpand
PTP1B antisense oligonucleot normalizes blood glucose, an sensitivity in diabetic mice
The role of protein-tyrosine phosphatase 1B (PTP1B) in diabetes Pl was investigated using an antisense oligonucleotide in ob/ob and the db/db mice. PTP1B antisense oligonucleotide treatmentExpand
Congenital Head and Neck Masses
A thyroglossal duct cyst is the most common congenital neck mass. Its evaluation and diagnosis can be performed with ultrasonongraphy that is noninvasive and cost-effective. A Sistrunk procedure isExpand