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A Dominant-negative p38 MAPK Mutant and Novel Selective Inhibitors of p38 MAPK Reduce Insulin-stimulated Glucose Uptake in 3T3-L1 Adipocytes without Affecting GLUT4 Translocation*
- R. Somwar, Sandra L Koterski, +7 authors A. Klip
- Biology, Medicine
- The Journal of Biological Chemistry
- 27 December 2002
Participation of p38 mitogen-activated protein kinase (p38) in insulin-induced glucose uptake was suggested using pyridinylimidazole p38 inhibitors (e.g. SB203580). However, the role of p38 in… Expand
Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression.
- Christian J Carlson, Sandra L Koterski, R. Sciotti, Germán Braillard Poccard, C. Rondinone
- Biology, Medicine
- 1 March 2003
Serine and threonine kinases may contribute to insulin resistance and the development of type 2 diabetes. To test the potential for members of the mitogen-activated protein (MAP) kinase family to… Expand
PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice
- B. A. Zinker, C. Rondinone, +19 authors M. Jirousek
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 8 August 2002
The role of protein-tyrosine phosphatase 1B (PTP1B) in diabetes was investigated using an antisense oligonucleotide in ob/ob and db/db mice. PTP1B antisense oligonucleotide treatment normalized… Expand
Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice.
Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin receptor (IR) signal transduction and a drug target for treatment of type 2 diabetes. Using PTP1B antisense oligonucleotides… Expand
T cell activation induces a noncoding RNA transcript sensitive to inhibition by immunosuppressant drugs and encoded by the proto-oncogene, BIC.
In a search for novel early T cell activation transcripts, we identified expressed sequence tags (ESTs) more abundantly expressed in normal human CD4(+) T lymphocytes fully activated by a 5 h… Expand
Management of a Tracheal Tear during Laryngopharyngoesophagectomy with Gastric Pull-up
Laceration of the posterior tracheal wall is one of the risks of transhiatal esophagectomy. Various methods of repairing such lacerations have been described; many of these methods involve a… Expand
P035: Continuing Trends in Awake Tracheotomy Airway Intervention
Objectives: (1) Understand patient and disease characteristics that necessitate urgent surgical airway intervention. (2) Learn which of these factors are predictive of decannulation. Methods: Here we… Expand
PTP1B antisense oligonucleot normalizes blood glucose, an sensitivity in diabetic mice
The role of protein-tyrosine phosphatase 1B (PTP1B) in diabetes Pl was investigated using an antisense oligonucleotide in ob/ob and the db/db mice. PTP1B antisense oligonucleotide treatment… Expand
Congenital Head and Neck Masses
A thyroglossal duct cyst is the most common congenital neck mass. Its evaluation and diagnosis can be performed with ultrasonongraphy that is noninvasive and cost-effective. A Sistrunk procedure is… Expand