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Circadian clocks govern a wide range of cellular and physiological functions in various organisms. Recent evidence suggests distinct functions of local clocks in peripheral mammalian tissues such as… Continue Reading
In mammals, circadian rhythms are generated by delayed negative feedback, in which period (PER1-PER3) and cryptochrome (CRY1, CRY2) proteins gradually accumulate in the nucleus to suppress the… Continue Reading
Targeted genome editing using CRISPR/Cas9 is a relatively new, revolutionary technology allowing for efficient and directed alterations of the genome. It has been widely used for loss-of-function… Continue Reading
Circadian clocks are molecular timekeeping mechanisms that allow organisms to anticipate daily changes in their environment. The fundamental cellular basis of these clocks is delayed negative… Continue Reading
ABSTRACT A ubiquitous feature of circadian clock across life forms is its organization as a network of coupled oscillators. Individual oscillators of the network often exhibit a considerable degree… Continue Reading
La presente invention concerne l'utilisation de substances organiques de filtration des UV pour la stabilisation de la physiologie circadienne ainsi que leur utilisation pour la modulation de… Continue Reading
L'invention concerne l'utilisation de conservateurs pour stabiliser la physiologie circadienne, ainsi que leur utilisation pour moduler l'expression genique de Klf9.
Use of organic UV filter substances for stabilizing the circadian physiology as well as their use for the modulation of the KLF9 gene expression.
Use of unsaturated terpenes and / or terpenoids for stabilizing the circadian physiology as well as their use for the modulation of the KLF9 gene expression.