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OBJECTIVE Primary myoadenylate deaminase deficiency (MADD) is probably the most frequent inborn metabolic myopathy with a prevalence of up to 2%. It is the result of mutations in the AMPDI gene, the most common of which is a C34-T transition in exon 2. The importance of the more rare mutation G468-T in exon 5 is uncertain. Primary objective was to elucidate(More)
INTRODUCTION Susceptibility to motion sickness (MS) is known to be affected by gender and ethnic origin, but whether gender and ethnicity are interacting is unknown. METHODS We investigated MS development in healthy Caucasian subjects (n = 227), and in subjects of Chinese origin (n = 82). All subjects were exposed to nausea-inducing body rotations in a(More)
BACKGROUND Within- and between-subject variability of susceptibility for motion sickness is well established, but which factors determine susceptibility is less well known. OBJECTIVE We investigated whether and to what degree sex, race, and head movements contribute to the development of nausea and vomiting (N&V) during pseudorotation in a vection drum in(More)
OBJECTIVES Pre-exposure to an environment in which a nausea-inducing body rotation will subsequently be given constitutes a latent inhibition procedure that might act to reduce anticipatory and postrotation nausea. METHODS This was tested in 24 healthy subjects randomly assigned to receive no pre-exposure (group 0), a single pre-exposure (group 1), or(More)
OBJECTIVE To investigate the role of Pavlovian conditioning and expectancy and of gender on the nocebo effects. METHODS Conditioning experiment: Forty-eight healthy male and female volunteers were investigated for 3 days using a standard rotation procedure. Subjects in the experimental group received a salient oral stimulus prior to rotation; subjects in(More)
BACKGROUND AND PURPOSE Length of survival of patients with low-grade glioma correlates with the extent of tumor resection. These tumors, however, are difficult to distinguish intraoperatively from normal brain tissue, often leading to incomplete resection. Our goal was to evaluate the effectiveness of intraoperative MR guidance in achieving gross-total(More)
A variety of intrinsic and extrinsic factors contribute to motion sickness severity in a stressful motion environment. The interplay of all these factors may partially explain the high inter-subject variability of motion sickness susceptibility found in many studies as well as some of the contradictory findings between studies regarding the modulating(More)
INTRODUCTION The purpose of this work was to investigate intrinsic (gender) and extrinsic factors (body position, visual pattern) and their relative contribution to the development of motion sickness during pseudo-rotation. METHODS A series of 3 experiments with 24, 12, and 48 subjects respectively, balanced for gender, was completed: Experiment 1(More)
REVIEWS A meta-analysis of the impact of bronchial stump coverage on the risk of bronchopleural fistula after pneumonectomy Comparing energy sources for surgical ablation of atrial fibrillation: a Bayesian network meta-analysis of randomized, controlled trials Paediatric subvalvular aortic stenosis: a systematic review and meta-analysis of natural history(More)
The authors report the case of a 10-year-old girl with intervertebral disc calcifications from the levels C6/C7 to Th1/Th2, presenting with a herniated calcified intervertebral disc at the C7/Th1 level, causing spinal cord compression with subsequent progressive paresis and sensory loss of her left leg. After anterior cervical discectomy and fusion the(More)