Sandra Hong

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Copper (Cu) is an essential trace element in the brain that can be toxic at elevated levels. Cu accumulation is a suspected etiology in several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and prion-induced disorders. Astrocytes are a proposed depot in the brain for Cu and other metals, including lead (Pb). This article(More)
Rapid and inexpensive methods are needed to investigate the interactions of complex mixtures. This commentary addresses the use of cell cultures to detect neurotoxicity of simple binary mixtures, which is a first step in the development of such methods. A small number of recent studies from our laboratory are examined. Though such studies are few, they(More)
In this paper we propose a theoretical framework of distributed representations and a methodology of representational analysis for the study of distributed cognitive tasksÑtasks that require the processing of information distributed across the internal mind and the external environment. The basic principle of distributed representations is that the(More)
  • Jiajie Zhang, Donald A Norman, David Kirsh, Jean Mandler, Mark St John, Hank Strub +3 others
  • 2003
In this article we propose a theoretical framework of distributed representations and a methodology of representational analysis for the study of dlstrlbuted cognl-tive tasks-tasks that require the pracesslng of lnformatlon distributed across the Internal mind and the external environment. The basic principle of distributed representations Is that the(More)
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