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Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy

• Isrid Sturm, Andrew G. Bosanquet, Sandra Hermann, Dilek Güner, Bernd Doerken, Peter Ted Daniel
• Cell Death and Differentiation
• 2003

AbstractInactivation of p53 has been shown to correlate with poor prognosis and drug resistance in malignant tumors. Nevertheless, few reports have directly shown such effects in primary tumor cells.… (More)

Analysis of p53/BAX in primary colorectal carcinoma: low BAX protein expression is a negative prognostic factor in UICC stage III tumors.

• Katharina Schelwies, Isrid Sturm, +9 authors Peter Ted Daniel
• International journal of cancer
• 2002

Deregulation of cell death pathways contributes to tumor development and to the clinical course of cancer disease. In patients with liver metastases of colorectal cancer, we have previously shown… (More)

Characterisation of hand small joints arthropathy using high-resolution MRI—Limited discrimination between osteoarthritis and psoriatic arthritis

• Leonie S. Braum, Dennis McGonagle, +7 authors K. G. Hermann
• European Radiology
• 2012

To test the hypothesis that microanatomical differences in joint disease localisation could be exploited using high-resolution MRI to better differentiate among rheumatoid arthritis (RA),… (More)

Monocyte alterations in rheumatoid arthritis are dominated by preterm release from bone marrow and prominent triggering in the joint

• Biljana Smiljanovic, Anna Maria Radzikowska, +17 authors Thomas Haeupl
• Annals of the rheumatic diseases
• 2018

OBJECTIVE Rheumatoid arthritis (RA) accompanies infiltration and activation of monocytes in inflamed joints. We investigated dominant alterations of RA monocytes in bone marrow (BM), blood and… (More)

Combined p53/Bax mutation results in extremely poor prognosis in gastric carcinoma with low microsatellite instability

• Alicja Mrozek, Henrik Petrowsky, +6 authors Peter Ted Daniel
• Cell Death and Differentiation
• 2003

AbstractGastric cancer is highly refractory to DNA-damaging therapies. We therefore studied both gene mutation and protein expression of p53 and Bax in a cohort of 116 patients with gastric cancer… (More)

Bax expression in benign and malignant thyroid tumours: dysregulation of wild-type P53 is associated with a high Bax and P21 expression in thyroid carcinoma.

• Sandra Hermann, Isrid Sturm, +4 authors Peter Ted Daniel
• International journal of cancer
• 2001

The purpose of our study was to determine the expression of the pro-apoptotic BAX protein in relation to the mutational status of BAX and p53 (as transcriptional activator of the BAX gene) in benign… (More)

Multigene analysis of Rb pathway and apoptosis control in esophageal squamous cell carcinoma identifies patients with good prognosis.

• Dilek Güner, Isrid Sturm, +7 authors Peter Ted Daniel
• International journal of cancer
• 2003

Deregulation of cell-cycle G(1)-restriction point control by disruption of Rb-pathway components is a frequent event in cancer. In concert with the inactivation of cell death pathways, such events… (More)

Single source dual-energy computed tomography in the diagnosis of gout: Diagnostic reliability in comparison to digital radiography and conventional computed tomography of the feet.

• Tobias Kiefer, Torsten Diekhoff, +5 authors K. G. Hermann
• European journal of radiology
• 2016

OBJECTIVES To investigate the diagnostic value of single-source dual-energy computed tomography (SDECT) in gouty arthritis and to compare its capability to detect urate depositions with digital… (More)

Osteitis: a retrospective feasibility study comparing single-source dual-energy CT to MRI in selected patients with suspected acute gout

• Torsten Diekhoff, Michael Scheel, Sandra Hermann, Jürgen Mews, B. Hamm, K. G. Hermann
• Skeletal Radiology
• 2016

Dual-energy computed tomography detects tophi in patients with chronic gout. However, other information that can be obtained from the same scan is not the focus of the current research, e.g., the… (More)

Patient Reported Outcomes (PROs) im rheumatologischen Praxisalltag – App hat sich bewährt

• Sarah Ohrndorf, Marie-Christin Weber, +9 authors Mareike Backhaus
• 2018

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