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Structural Analysis of the Mitotic Regulator hPin1 in Solution
Domain organization of hPin1 differs from that observed in structures solved by x-ray crystallography, and NMR-based data revealed only weak interaction of both domains at their interface in solution, indicating that the flexible linker, connecting both domains, promotes binding. Expand
Human TPST1 transmembrane domain triggers enzyme dimerisation and localisation to the Golgi compartment.
In vivo FRET studies using the transmembrane domain suggest that the human tyrosylprotein sulfotransferase may be functional as homodimer/oligomer in the trans-Golgi compartment. Expand
Shear stress mediates tyrosylprotein sulfotransferase isoform shift in human endothelial cells.
In this study, we examined expression of tyrosylprotein sulfotransferase (TPST) isoforms TPST1 and TPST2 in primary cultures of human umbilical vein endothelial cells. For the first time coexpressionExpand
Structural attributes in the conjugation of ubiquitin, SUMO and RUB to protein substrates
Many cellular and secreted proteins are chemically modified after their translation is completed. The covalent linkage of a polypeptide chain (modifier) to a substrate protein is a special case ofExpand
Structural attributes in the conjugation of ubiquitin, SUMO and RUB to protein substrates.
The homologies and differences of these proteins are described and salient topological hallmarks common to modifier-conjugating enzymes are indicated, which will help in understanding these regulatory pathways and their similarities and differences in controlling protein fate. Expand
ATP, a trigger for pain signaling
The fact that ATP binding to the P2X3 receptor triggers the sensation of pain and mediates the voiding frequency of the urinary bladder opens a new field for drug targeting, which will result in the development of a new generation of painkillers and of substances to control urinary bladder volume reflexes. Expand
Solution structure of human Pin1