• Publications
  • Influence
Soluble Guanylate Cyclase Stimulation Prevents Fibrotic Tissue Remodeling and Improves Survival in Salt-Sensitive Dahl Rats
Background A direct pharmacological stimulation of soluble guanylate cyclase (sGC) is an emerging therapeutic approach to the management of various cardiovascular disorders associated withExpand
  • 71
  • 4
  • PDF
Nitric oxide-independent stimulation of soluble guanylate cyclase reduces organ damage in experimental low-renin and high-renin models
Objectives The nitric oxide–soluble guanylate cyclase (sGC)–cGMP signal transduction pathway is impaired in different cardiovascular diseases, including pulmonary hypertension, heart failure andExpand
  • 69
&agr;1-A680T Variant in GUCY1A3 as a Candidate Conferring Protection From Pulmonary Hypertension Among Kyrgyz Highlanders
Background—Human variation in susceptibility to hypoxia-induced pulmonary hypertension is well recognized. High-altitude residents who do not develop pulmonary hypertension may host protective geneExpand
  • 14
  • PDF
Riociguat prevents fibrotic tissue remodelling and improves survival in salt-sensitive Dahl rats
Background A direct pharmacological stimulation of soluble guanylate cyclase (sGC) is an emerging therapeutic approach to the management of various cardiopulmonary disorders associated withExpand
  • 2
Cardio-renal protection of riociguat (BAY 63-2521) in low- and high-renin models of hypertension
Address: 1Department of Nephrology, Charite, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany, 2Center for Cardiovascular Research, Department of Pharmacology and Toxicology, Charite,Expand
Soluble guanylate cyclase stimulator riociguat reduces organ damage in experimental models of hypertension
Evgenov OV, Pacher P, Schmidt PM, Hasko G, Schmidt HH, Stasch JP. Nat Rev Drug Discov 2006;5:755–68. Review. Kalk P, Godes M, Relle K, Rothkegel C, Hucke A, Stasch JP, Hocher B. Br J PharmacolExpand