Learn More
The Evolved Packet Core (EPC), defined by 3GPP, provides the possibility of integrating 3GPP as well as non-3GPP access network technologies. This opens up new options for mobility through the use of inter system handover over several access network technologies. This paper provides an overview of the introduced component Access Network Discovery and(More)
Interleukin 10 receptor (IL10R)-deficient mice develop spontaneous colitis and, similarly, patients with loss-of-function mutations in IL10R develop severe infant-onset inflammatory bowel disease. Loss of IL10R signaling in mouse and human macrophages is associated with increased production of interleukin 1β. We demonstrated that innate immune production of(More)
Protease serine member S31 (Prss31)/transmembrane tryptase/tryptase-γ is a mast cell (MC)-restricted protease of unknown function that is retained on the outer leaflet of the plasma membrane when MCs are activated. We determined the nucleotide sequences of the Prss31 gene in different mouse strains and then used a Cre/loxP homologous recombination approach(More)
BACKGROUND This study describes the transmission of border disease virus (BDV) from a persistently infected calf to seronegative heifers in early pregnancy, resulting in persistently infected fetuses. On day 50 of pregnancy (= day 0 of the infection phase), six heifers were co-housed in a free stall with a bull calf persistently infected with BDV (pi BVD)(More)
OBJECTIVE Epithelial to mesenchymal transition (EMT) seems to play an important role in the pathogenesis of fistulae, a common clinical complication of Crohn's disease (CD). TGFβ and interleukin-13 (IL-13) have been correlated with the onset of EMT-associated organ fibrosis and high levels of TGFβ have been shown in transitional cells (TCs) lining CD(More)
Anal adenocarcinomas arising from perianal fistulae represent a rare complication in Crohn's disease (CD) patients. We have previously demonstrated the involvement of an epithelial-to-mesenchymal transition (EMT) in the pathogenesis of CD-associated fistulae. Although EMT has also been implicated in the development of colorectal and anal carcinoma, the(More)
Evolving mobile communication technologies like the Evolved Packet Core (EPC), specified by 3GPP, aim to incorporate more distinct access technologies. While mobility management and QoS aspects are consistently defined for 3GPP technologies, not all non-3GPP networks are integrated smoothly. This work aims, using close to reality simulations with ns-3, to(More)
The requirements on networks referring to bandwidth, QoS and mobility are increasing because of the huge traffic growth, the increasing amount of mobile devices and the always-on-demand from subscribers, no matter if the end user devices are stationary or moving. The predicted growth and the fulfilment of the QoS and mobility requirements must be(More)
The number of mobile devices, such as smartphones, netbooks, notebooks, etc. will increase in the next few years and with the availability of Long Term Evolution (LTE) capable devices and networks the data rates are increasing. As a result of this, the data traffic volume will massively increase by 2015 and therefore the core and access networks have to be(More)
In order to manage the exponential growth of traffic in mobile network environments and the increasing requirements on bandwidth, Quality of Service (QoS) and mobility, the Mobile Network Operators (MNOs) infrastructure has to provide for an appropriate traffic distribution among the available networks. This paper proposes a new real-time traffic(More)