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Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated mutations in mtDNA are unclear. In this study, we analyzed somatic alterations in mtDNA from 1675 tumors. We identified 1907 somatic(More)
Genome-wide DNA sequencing was used to decrypt the phylogeny of multiple samples from distinct areas of cancer and morphologically normal tissue taken from the prostates of three men. Mutations were present at high levels in morphologically normal tissue distant from the cancer, reflecting clonal expansions, and the underlying mutational processes at work(More)
Disorders in skin wound healing are a major health problem that requires the development of innovative treatments. The use of biomaterials as an alternative of skin replacement has become relevant, but its use is still limited due to poor vascularization inside the scaffolds, resulting in insufficient oxygen and growth factors at the wound site. In this(More)
Metastasis is a major factor associated with poor prognosis in cancer, but little is known of its molecular mechanisms. Although the clinical behavior of soft tissue sarcomas is highly variable, few reliable determinants of outcome have been identified. New markers that predict clinical outcome, in particular the ability of primary tumors to develop(More)
Our goal is to develop an automated assessment and training procedure for children with eye-hand coordination problem. An automated assessment system is expected to reduce the burden and the associated cost of having a trained professional present at any assessment, or training session. The intelligent decision support system will be based upon a fuzzy(More)
In this paper we discuss the possibility of improving eye-hand coordination in children diagnosed with this problem, using a robotic mapping from a haptic user interface to a virtual environment. Our goal is to develop an assessment and training procedure that will result in improving handwriting taking advantage of the force feedback provided by the haptic(More)
Health, welfare and production problems of organic suckling piglets are poorly known due to a lack of information from commercial farms and the paucity of experiments run under organic standards. However, taking into account the accumulated knowledge on the biology of pigs, the few results obtained in organic pig production and those from conventional(More)
With the aim to identify health and welfare strategies in organic pig production, a description of the different organic production systems was realized in eight European countries (Austria, Denmark, France, Germany, Italy, Sweden, Switzerland and UK). This description was based on the following features: numbers of organic farms and organic pigs, market(More)