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—All-optical Boolean XOR is demonstrated on a 20 Gb/s pseudodata pattern using a semiconductor optical amplifier based ultrafast nonlinear interferometer (UNI) switch. Bit pattern switching with low-pattern dependence and low switching energies is achieved.
BACKGROUND Muckle-Wells-syndrome (MWS) is an autoinflammatory disease characterized by systemic and organ-specific inflammation due to excessive interleukin (IL)-1 release. Inner ear inflammation results in irreversible sensorineural hearing loss, if untreated. Early recognition and therapy may prevent deafness. The aims of the study were to characterize… (More)
OBJECTIVES Muckle-Wells syndrome (MWS) is an autoinflammatory disease characterized by excessive interleukin-1 (IL-1) release, resulting in recurrent fevers, sensorineural hearing loss, and amyloidosis. IL-1 inhibition with anakinra, an IL-1 receptor antagonist, improves clinical symptoms and inflammatory markers. Subclinical disease activity is commonly… (More)
Dedication I dedicate this dissertation to my brothers and sisters in blindness, for we see things in a manner that the sighted world may not fully understand. v Acknowledgements The path that I have taken not only to complete my dissertation but also to achieve my doctoral degree has not been ventured into alone. Many people have supported me throughout… (More)
BACKGROUND Juvenile idiopathic arthritis (JIA) is a chronic illness with a high risk of developing long-term disability. Disease activity is currently being monitored and quantified by ACR core set. Here, joint inflammation is determined; however joint function is the crucial component for developing disability. The aim of this study was to quantify and… (More)
Purpose Muckle-Wells syndrome (MWS) is a rare inherited auto-inflammatory disease. Patients may present with fever, rash, arthralgia, or conjunctivitis. Effective treatment of MWS has become available with the advance of IL-1 inhibition preventing disease sequalae of sensorineural deafness and amyloidosis. Therefore, early diagnosis of MWS is crucial to… (More)