Sandra Aliberti

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BACKGROUND Patellofemoral Pain Syndrome is one of the most common knee disorders among physically active young women. Despite its high incidence, the multifactorial etiology of this disorder is not fully understood. OBJECTIVES To investigate the influence of Patellofemoral Pain Syndrome on plantar pressure distribution during the foot rollover process(More)
OBJECTIVES To investigate plantar pressure distribution in individuals with and without Patellofemoral Pain Syndrome during the support phase of stair descent. DESIGN Observational case-control study. PARTICIPANTS 30 young adults with Patellofemoral Pain Syndrome and 44 matched controls. MAIN OUTCOME MEASURES Contact area, peak pressure and(More)
The aim of the study was to determine the activity and toxicity of melphalan as a single agent given in up-front therapy for patients with newly-diagnosed Ewing's family tumours with bone/bone marrow metastases. Nineteen patients were enrolled from 2001 to 2004. The treatment consisted of up-front therapy with melphalan (two courses of 50 mg/m2, 3 weeks(More)
BACKGROUND A phase 2 trial was carried out to assess the antineoplastic activity of 2 courses of cyclophosphamide-etoposide in relapsed osteosarcoma patients. METHODS Twenty-six relapsed osteosarcoma patients with a median age of 18.5 years (8.3-47.1) were enrolled. Seven patients were in first relapse (27%), 11 in second relapse (42%), 7 in third relapse(More)
Leiomyosarcoma represents about 24% of all soft tissue sarcomas and can originate from retroperitoneum, uterus, or extremities. Adequate local control may be achieved with surgery and radiotherapy. In the presence of unresectable metastases either doxorubicin- or gemcitabine-based chemotherapy is the standard of treatment. Nevertheless, prognosis remains(More)
The existence of a graft versus tumor (GVT) effect of donor-derived T cells after allogeneic hematopoietic stem cell transplantation is well established as a critical component for the success of the procedure in several hematologic malignancies. Although it has been suggested that a GVT effect might also be generated in patients affected by refractory(More)
10061 Background: Cardiovascular events (CVE), i.e. CHF and coronary artery disease (CAD), may occur in up to 10% of patients (pts) affected by GIST and RCC treated with SU. CVE recognition, SU interruption and appropriate therapy based on ACE inhibitors and/or β blockers, are the only effective treatment for this severe complication. As of today, CVE known(More)
Enhancing the antitumor activity of the DNA-damaging drugs is an attractive strategy to improve current treatment options. Trabectedin is an isoquinoline alkylating agent with a peculiar mechanism of action. It binds to minor groove of DNA inducing single- and double-strand-breaks. These kinds of damage lead to the activation of PARP1, a first-line enzyme(More)
e20514 Background: After a decade of IM, the efficacy and toxicity of this drug are well known. However, there is a surprising paucity of data regarding IM treatment in elderly patients (pts) both in chronic myeloid leukemia as well as in GIST. Indeed, though encompassing elder patients, the largest published series, the metaGIST study, reported a median(More)