The pathogenesis of glucocorticoid-induced (GC-induced) bone loss is unclear. For example, osteoblast apoptosis is enhanced by GCs in vivo, but they stimulate bone formation in vitro. This conundrum suggests that an intermediary cell transmits a component of the bone-suppressive effects of GCs to osteoblasts in the intact animal. Bone remodeling is… (More)
In vitro infection of murine peritoneal macrophages with the protozoan Leishmania donovani has been found to alter the signaling parameters of the host. The present study indicates that the enhancement of intracellular ceramide level in macrophages after infection is a major event relating to macrophage dysfunction. We have previously demonstrated that… (More)
Type 1 diabetes is characterized by a chronic inflammatory response resulting in the selective destruction of the insulin-producing beta cells. We have previously demonstrated that dendritic cells (DCs) prepared from nonobese diabetic (NOD) mice, a model for spontaneous type 1 diabetes, exhibit hyperactivation of NF-kappaB resulting in an increased capacity… (More)
The protein kinase C (PKC) family regulates macrophage function involved in host defense against infection. In the case of Leishmania donovani infection, the impairment of PKC-mediated signaling is one of the crucial events for the establishment of parasite into the macrophages. Earlier reports established that C-C chemokines mediated protection against… (More)
We discuss the generalization of recently discovered BPS configurations, corresponding to the planar string networks, to non-planar ones by considering the U-duality symmetry of type II string theory in various dimensions. As an explicit example, we analyze the string solutions in 8-dimensional space-time, carrying SL(3) charges, and show that by aligning… (More)
We present a class of static membrane solutions, with non-flat worldvolume geometry, in the eleven dimensional supergravity with source terms. This class of solutions contains supersymmetric as well as a large class of non-supersymmetric configurations. We comment about near horizon limit and stability of these solutions and point out an interesting… (More)
We study a three-dimensional gauge theory obtained from the dimensional reduction of a D4-brane worldvolume theory in the background of space-time moduli. An SL(3) symmetry in this theory, which acts on fields as well as coupling constants, is identified. By comparing the energies with the string tensions, we show that certain 1/2 supersymmetric classical… (More)
A rare malposition of central venous catheter in the left superior intercostal vein is described. The diagnostic features and the possible ways to prevent this complication are discussed.